标题：Anti-Human RAGE Antibody (XT-M4) 抗体 (RHH01901)，AntibodySystem Laboratories

名称：抗体 Anti-Human RAGE Antibody (XT-M4) 抗体

别名: RAGE 抗体;XT-M4 抗体；RAGE;XT-M4；抗体

链接：https://antibodysystem.com/product/9634.htm

产品购买联系方式：027-65279366 /18162686757

邮箱：biolab-reagents@atagenix.com

QQ：2663991332

货号：RHH01901

宿主:Human

寄主物种：Human

形式：Liquid

纯度：>95% by SDS-PAGE.

克隆性：Monoclonal

同种型：IgG1

靶点：RAGE/AGER

应用：ELISA,Neut

储存：Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term.

参考文献：

Pharmacokinetics and lung distribution of a humanized anti-RAGE antibody in wild-type and RAGE-/- mice

Yulia Vugmeyster 1, David DeFranco, Debra D Pittman, Xin Xu

Affiliations expand

PMID: 20978371 PMCID: PMC2958578 DOI: 10.4161/mabs.2.5.13089

Free PMC article

Abstract

A neutralizing antibody to the receptor for the advanced glycation end products (anti-RAGE Ab) was developed as a potential treatment of acute and chronic inflammatory conditions. Previous pharmacology studies demonstrated efficacy of the anti-RAGE antibody in the mouse model of sepsis. We examined pharmacokinetics and lung distribution of [125I]anti-RAGE Ab in RAGE-/- and wild-type (129S5) mice following single IV administration. Serum pharmacokinetics of [125I]anti-RAGE Ab was similar in RAGE-/- and 129S5 mice, with the total body clearance of 0.3 mL/hr/kg and the elimination half-life of 11-12 days, suggesting the target expression had limited impact on overall elimination of [125I]anti-RAGE Ab from mice. [125I]Anti-RAGE Ab accumulated in the lung of 129S5 mice, with ~4% of total dose retained in the lung at days 6-27 and the lung AUC0-∞ of ~300% of that in serum. The SDS-PAGE analysis suggested that most of retained lung radioactivity was attributed to intact antibody. No accumulation of radioactivity was observed in the lung of RAGE-/- mice, indicating that lung uptake of [125I]anti-RAGE Ab was target-dependent in wild-type mice. These data suggest that the anti-RAGE Ab was able to localize to the site of RAGE expression, the lung, and support the findings in the previous pharmacology studies.

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