标题：Anti-Human TSHR/LGR3 Antibody (K1-70)抗体,AntibodySystem Laboratories

链接：https://www.antibodysystem.com/product/7264.html

名称：Anti-Human TSHR/LGR3 Antibody (K1-70)抗体

别名：Thyroid-stimulating hormone receptor, TSH-R, TSHR, Thyrotropin receptor, LGR3, RHD18102

货号：FHD18120

宿主：Mouse

适用物种：Human

存储缓冲区：0.01M PBS, pH 7.4.

形式：Liquid

纯度：>95%

克隆：Monoclonal

同型：IgG2a, lambda

应用：Block, ELISA, FCM

内毒素水平：Please contact with the lab for this information.

UniProt：P16473

用途范围：仅用于科研

储存：Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term.

产品购买联系方式：027-65279366 /18162686757

邮箱：biolab-reagents@atagenix.com

QQ：2663991332

参考文献：

A review of TSHR- and IGF-1R-related pathogenesis and treatment of Graves' orbitopathy. PMID: 36742308

Mechanisms of Action of TSHR Autoantibodies. PMID: 26361260

Modulation of TSHR signaling by posttranslational modifications. PMID: 17524661

Central Tolerance Mechanisms to TSHR in Graves' Disease: Contributions to Understand the Genetic Association. PMID: 30396220

TSHR-based chimeric antigen receptor T cell specifically deplete auto-reactive B lymphocytes for treatment of autoimmune thyroid disease. PMID: 37690235

Controversial constitutive TSHR activity: patients, physiology, and in vitro characterization. PMID: 24845969

Genetics of Graves' Disease: Special Focus on the Role of TSHR Gene. PMID: 26361261

Presence of TSHR in NK Cells and Action of TSH on NK Cells. PMID: 34392245

Signaling Dynamics of TSHR-Specific CAR-T Cells Revealed by FRET-Based Biosensors. PMID: 35252208

Variant of TSHR is Not a Frequent Cause of Congenital Hypothyroidism in Chinese Han Patients. PMID: 34377013

Association between TSHR gene methylation and papillary thyroid cancer: a meta-analysis. PMID: 32279226

LGR4: A New Receptor Member in Endocrine and Metabolic Diseases. PMID: 36791020

The biology and evolution of the Dilp8-Lgr3 pathway: A relaxin-like pathway coupling tissue growth and developmental timing control. PMID: 29715504

Sex-specific regulation of Lgr3 in Drosophila neurons. PMID: 26884206

Tumour-derived Dilp8/INSL3 induces cancer anorexia by regulating feeding neuropeptides via Lgr3/8 in the brain. PMID: 33558728

Drosophila Lgr3 Couples Organ Growth with Maturation and Ensures Developmental Stability. PMID: 26441350

Mating activates neuroendocrine pathways signaling hunger in Drosophila females. PMID: 37184218

[Some insulins to orchestrate growth]. PMID: 28990566

Dilp8 requires the neuronal relaxin receptor Lgr3 to couple growth to developmental timing. PMID: 26510564

The steroid-hormone ecdysone coordinates parallel pupariation neuromotor and morphogenetic subprograms via epidermis-to-neuron Dilp8-Lgr3 signal induction. PMID: 34099654

A brain circuit that synchronizes growth and maturation revealed through Dilp8 binding to Lgr3. PMID: 26429885

Systemic signalling and local effectors in developmental stability, body symmetry, and size. PMID: 31225459

Growth Coordination During Drosophila melanogaster Imaginal Disc Regeneration Is Mediated by Signaling Through the Relaxin Receptor Lgr3 in the Prothoracic Gland. PMID: 27558136

Drosophila Insulin-Like Peptide 8 (DILP8) in Ovarian Follicle Cells Regulates Ovulation and Metabolism. PMID: 32849266

TSH receptor specific monoclonal autoantibody K1-70(TM) targeting of the TSH receptor in subjects with Graves' disease and Graves' orbitopathy-Results from a phase I clinical trial. PMID: 35088429

Hormone- and antibody-mediated activation of the thyrotropin receptor. PMID: 35940204

Structure of full-length TSH receptor in complex with antibody K1-70. PMID: 36069797

Mechanisms of Action of TSHR Autoantibodies. PMID: 26361260

Blocking type TSH receptor antibodies. PMID: 26000138

Blocking the Thyrotropin Receptor with K1-70 in a Patient with Follicular Thyroid Cancer, Graves' Disease, and Graves' Ophthalmopathy. PMID: 34114495

Preclinical studies on the toxicology, pharmacokinetics and safety of K1-70(TM) a human monoclonal autoantibody to the TSH receptor with TSH antagonist activity. PMID: 32257067

In vivo effects of a human thyroid-stimulating monoclonal autoantibody (M22) and a human thyroid-blocking autoantibody (K1-70). PMID: 26000124

Management of Graves' hyperthyroidism: present and future. PMID: 35287535

Investigational drugs in early stage clinical trials for thyrotoxicosis with hyperthyroidism. PMID: 30354697

Monoclonal Antibodies for the Treatment of Graves Orbitopathy: Precision Medicine? PMID: 36727923

Analytical Performance and Validation of a Bioassay for Thyroid-Blocking Antibodies. PMID: 26956921

Crystal structure of the TSH receptor (TSHR) bound to a blocking-type TSHR autoantibody. PMID: 21247981

Similarities and differences in interactions of thyroid stimulating and blocking autoantibodies with the TSH receptor. PMID: 22829655

CAR-T Cells Targeting TSHR Demonstrate Safety and Potent Preclinical Activity Against Differentiated Thyroid Cancer. PMID: 34751400

Glycosylation pattern analysis of glycoprotein hormones and their receptors. PMID: 27875255

Performance and Specificity of 6 Immunoassays for TSH Receptor Antibodies: A Multicenter Study. PMID: 29071236

TSH receptor - autoantibody interactions. PMID: 19530271

Inhibition of TSH/IGF-1 Receptor Crosstalk by Teprotumumab as a Treatment Modality of Thyroid Eye Disease. PMID: 34788857

A rapid homogenous bioassay for detection of thyroid-stimulating antibodies based on a luminescent cyclic AMP biosensor. PMID: 34871593

Novel Approaches for Immunosuppression in Graves' Hyperthyroidism and Associated Orbitopathy. PMID: 33511082

Experimental Reproduction of Dynamic Fluctuation of TSH Receptor-Binding Antibodies Between Stimulation and Inhibition. PMID: 31745531

Crystal structure of a ligand-free stable TSH receptor leucine-rich repeat domain. PMID: 30689545

Monoclonal autoantibodies to the TSH receptor, one with stimulating activity and one with blocking activity, obtained from the same blood sample. PMID: 20550534

Thyroid stimulating hormone exhibits the impact on LDLR/LDL-c via up-regulating hepatic PCSK9 expression. PMID: 28987238

Hypothalamic-pituitary-thyroid axis hormones stimulate mitochondrial function and biogenesis in human hair follicles. PMID: 23949722

A novel bioassay for anti-thyrotrophin receptor autoantibodies detects both thyroid-blocking and stimulating activity. PMID: 23647395

PDGF enhances orbital fibroblast responses to TSHR stimulating autoantibodies in Graves' ophthalmopathy patients. PMID: 22438231

Insight into thyroid-stimulating autoantibody interaction with the thyrotropin receptor N-terminus based on mutagenesis and re-evaluation of ambiguity in this region of the receptor crystal structure. PMID: 21834684