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| 产地 | France |
| 保存条件 | |
| 品牌 | abinscience |
| 货号 | DB714018 |
| 用途 | 供科研使用 |
| 检测方法 | Colorimetric |
| 保质期 | 1 year |
| 适应物种 | Not Species Specific |
| 检测限 | |
| 数量 | 999 |
| 包装规格 | 96T |
| 标记物 | Unconjugated |
| 样本 | Plasma, Serum |
| 应用 | ELISA |
| 是否进口 |
| Product name | Talacotuzumab ELISA Kit |
|---|---|
| Catalog No. | DB714018 |
| Applications | ELISA |
| Accession | P26951 |
| Stability and Storage | The stability of ELISA kit is determined by the loss rate of activity. The loss rate of this kit is less than 10% prior to the expiration date under appropriate storage condition. |
| Detection method | Colorimetric |
| Sample type | Plasma, Serum |
| Assay type | Quantitative |
| Sensitivity | 0.156 μg/ml |
| Background | Talacotuzumab (JNJ 56022473; CSL 362) is an IgG1-type fully humanized, CD123-neutralizing monoclonal antibody containing a modified Fc structure. Talacotuzumab has KDs of 0.43 nM, 188 nM, 46 nM, 16.8 nM for CD123, CD32b/c, CD16-158F, CD16-158V, respectively. Talacotuzumab inhibits IL-3 binding to CD123, antagonizing IL-3 signaling in target cells. Talacotuzumab has mutated the Fc region to increase affinity for CD16 (FcγRIIIa), thereby enhancing antibody-dependent cell-mediated cytotoxicity (ADCC). Talacotuzumab is highly effective in vivo reducing leukemic cell growth in acute myeloid leukemia (AML) xenograft mouse models. |
| Target | Talacotuzumab |
| Range | 0.31-5 μg/mL |
| Recovery | 80-120% |
| Alternative Names | CSL-362-AML, CSL362, JNJ-56022473, CAS: 1826831-79-1 |
| Clone ID | \ |
| Shipping | 2-8 ℃ |
| Note | For Research Use Only. |
Abinscience, founded in 2023 and located in the innovation technology center in Strasbourg, France, is the core research reagent brand of ProteoGenix. Focusing on the development and production of life science research reagents, Abinscience takes "Empowering Bioscience Discovery" as its vision, and is committed to providing high-quality and innovative biological reagent products and technical solutions for global researchers.
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