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| 产地 | France |
| 保存条件 | |
| 品牌 | abinscience |
| 货号 | DY257028 |
| 用途 | 供科研使用 |
| 检测方法 | Colorimetric |
| 保质期 | 1 year |
| 适应物种 | Not Species Specific |
| 检测限 | |
| 数量 | 999 |
| 包装规格 | 96T |
| 标记物 | Unconjugated |
| 样本 | Plasma, Serum |
| 应用 | ELISA |
| 是否进口 |
| Product name | Afutuzumab ELISA Kit |
|---|---|
| Catalog No. | DY257028 |
| Applications | ELISA |
| Accession | P11836 |
| Stability and Storage | The stability of ELISA kit is determined by the loss rate of activity. The loss rate of this kit is less than 10% prior to the expiration date under appropriate storage condition. |
| Detection method | Colorimetric |
| Sample type | Plasma, Serum |
| Assay type | Quantitative |
| Sensitivity | 0.156 μg/ml |
| Background | Afutuzumab is a monoclonal antibody that targets the CD20 antigen expressed on the surface of pre-B and mature B lymphocytes. Upon binding to CD20, obinutuzumab mediates B-cell lysisthrough (1) engagement of immune effector cells (2) by directly activating intracellular death signaling pathways (direct cell death), and/or (3) activation of the complement cascade. The immune effector cell mechanisms include antibody-dependent cellular cytotoxicity (ADCC) and antibodydependent cellular phagocytosis.As an antibody with reduced fucose content, obinutuzumab induces greater ADCC activity than rituximab in vitro using human cancer cell lines. Afutuzumab also demonstrated an increased ability to induce direct cell death when compared to rituximab. Afutuzumab binds to FcγRIII using purified proteins with a higher affinity than rituximab. Afutuzumab and rituximab bind with similar affinity to overlapping epitopes on CD20. |
| Target | Afutuzumab |
| Range | 0.31-5 μg/mL |
| Recovery | 80-120% |
| Alternative Names | GA101,RG7159,RO5072759,CAS: 949142-50-1 |
| Clone ID | \ |
| Shipping | 2-8 ℃ |
| Note | For Research Use Only. |
Abinscience, founded in 2023 and located in the innovation technology center in Strasbourg, France, is the core research reagent brand of ProteoGenix. Focusing on the development and production of life science research reagents, Abinscience takes "Empowering Bioscience Discovery" as its vision, and is committed to providing high-quality and innovative biological reagent products and technical solutions for global researchers.
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