武汉艾必赛生物有限公司推荐Anti-Human TACE/ADAM17 Recombinant Antibody (1022C3),精品抗体

链接：https://www.abinscience.cn/product/40/3660.html

名称：Anti-Human TACE/ADAM17 Recombinant Antibody (1022C3)

货号：HX200107

种属反应性：Human

应用：FCM

宿主：Mouse

克隆类型：Monoclonal

同种型：IgG1, kappa

克隆号：1022C3

靶标：TACE, Snake venom-like protease, ADAM17, CD156b, CSVP, ADAM 17, Disintegrin and metalloproteinase domain-containing protein 17, TNF-alpha convertase, TNF-alpha-converting enzyme

内毒素水平：Please contact with the lab for this information.

纯度：>95% as determined by SDS-PAGE.

纯化方式：Protein A/G purified from cell culture supernatant.

Accession号：P78536

状态：Liquid

用途范围：仅用于科研

储存：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

产品介绍：Anti-Human TACE/ADAM17 Recombinant Antibody (1022C3)｜HX200107 是艾必赛生物（abinScience）推出的小鼠源重组单克隆抗体（IgG1, κ，克隆号 1022C3），靶向人源 ADAM17（又称 TACE / CD156b，TNF-α 转化酶），可作为细胞表面金属蛋白酶检测、ADAM17 表达与脱落酶活性分析、炎症因子释放机制研究的阳性/参照质控工具。该抗体以重组人 ADAM17 蛋白为免疫原，经 Protein A/G 从细胞培养上清中纯化，SDS-PAGE 纯度 >95%，批次一致性好，适用于流式细胞术（FCM）；以液体形式保存在 0.01M PBS, pH 7.4 中。频繁使用可 2–8°C 短期存放（1–2 周），长期建议 -20°C（12 个月）或 -80°C 避反复冻融保存。（RUO，仅限科研/非临床用途）

ADAM17（去整合素-金属蛋白酶 17）是一种约 93 kDa 的 I 型跨膜锌依赖性金属蛋白酶，因能剪切膜结合型 pro-TNF-α 释放可溶性 TNF-α 而得名 TACE。它是介导“胞外域脱落”的关键酶，底物覆盖炎症、免疫、发育等多个通路中的重要跨膜蛋白，包括 TNF-α 前体、TNFR（p55/p75）、IL-1RII、TGF-α、L-selectin、MUC1、ACE2、IL-6R、LAG3、TREM2、JAM3 及 APP 等，并可切割 Notch 受体激活 Notch 信号通路。由于 ADAM17 在炎症因子成熟、免疫调节、EGFR 配体释放及肿瘤微环境重塑中发挥不可替代的作用，它既是流式检测细胞表面 ADAM17 表达与激活状态的核心靶点，也是抗炎药物（TACE 抑制剂）、肿瘤靶向治疗及病毒-宿主互作（如 ACE2 加工）研究的重要方向；配合 TNF-α、IL-6R、Notch 等相关抗体，可共同支撑炎症性疾病机制解析、靶点验证与药物筛选平台。

产品购买联系方式：027-87433958/17302791434

邮箱：info@abinscience.com

参考文献：

TACE/ADAM17 processing of EGFR ligands indicates a role as a physiological convertase. PMID: 12814936

Tace/ADAM17 is a bi-directional regulator of axon guidance that coordinates distinct Frazzled and Dcc receptor signaling outputs. PMID: 36476876

Prefrontal cortical protease TACE/ADAM17 is involved in neuroinflammation and stress-related eating alterations. PMID: 36747666

Amphiregulin. PMID: 24463227

TACE/ADAM17 substrates associate with ACS (Ep-CAM, HB-EGF) and follow-up MACE (TNFR1 and TNFR2). PMID: 36643799

TACE (ADAM17) inhibits Schwann cell myelination. PMID: 21666671

TACE/ADAM17 is involved in germ cell apoptosis during rat spermatogenesis. PMID: 20501791

TACE/ADAM17 is essential for oligodendrocyte development and CNS myelination. PMID: 25186737

Role of the prefrontal cortical protease TACE/ADAM17 in neurobehavioral responses to chronic stress during adolescence. PMID: 38715397

Role of tumour necrosis factor alpha converting enzyme (TACE/ADAM17) and associated proteins in coronary artery disease and cardiac events. PMID: 29097110

Characterization of the tumour necrosis factor alpha-converting enzyme, TACE/ADAM17. PMID: 10093737

Multi-targeting TACE/ADAM17 and gamma-secretase of notch signalling pathway in TNBC via drug repurposing approach using Lomitapide. PMID: 36423860

Erratum: Palazuelos et al., "TACE/ADAM17 Is Essential for Oligodendrocyte Development and CNS Myelination". PMID: 38092526

Oligodendrocyte Regeneration and CNS Remyelination Require TACE/ADAM17. PMID: 26338334

Astragaloside III activates TACE/ADAM17-dependent anti-inflammatory and growth factor signaling in endothelial cells in a p38-dependent fashion. PMID: 32197276

TACE/ADAM17-TNF-alpha pathway in rat cortical cultures after exposure to oxygen-glucose deprivation or glutamate. PMID: 11973430

Inhibitory role of TACE/ADAM17 cytotail in protein ectodomain shedding. PMID: 22125668

Impaired mechanical, heat, and cold nociception in a murine model of genetic TACE/ADAM17 knockdown. PMID: 30586315

Up-regulation of TNF-alpha convertase (TACE/ADAM17) after oxygen-glucose deprivation in rat forebrain slices. PMID: 11406201

Extracellular RNA drives TNF-α/TNF-receptor-1 mediated cardiac ischemia/reperfusion injury: Mechanistic insights and therapeutic potential of RNase1. PMID: 40946941

A biosensor for the activity of the "sheddase" TACE (ADAM17) reveals novel and cell type-specific mechanisms of TACE activation. PMID: 25714465

Involvement of TACE/ADAM17 and ADAM10 in etoposide-induced apoptosis of germ cells in rat spermatogenesis. PMID: 21503882

Expression of Concern: Palazuelos et al., "TACE/ADAM17 is Essential for Oligodendrocyte Development and CNS Myelination". PMID: 34326149

MT1-MMP mediates MUC1 shedding independent of TACE/ADAM17. PMID: 15130087

Protein kinase C (PKC) increases TACE/ADAM17 enzyme activity in porcine ovarian somatic cells, which is essential for granulosa cell luteinization and oocyte maturation. PMID: 24424050

iNOS promotes CD24(+)CD133(+) liver cancer stem cell phenotype through a TACE/ADAM17-dependent Notch signaling pathway. PMID: 30297396

Expression of Concern: Palazuelos et al., "Oligodendrocyte Regeneration and CNS Remyelination Require TACE/ADAM17". PMID: 34326147

Anti-tumor efficacy of an MMAE-conjugated antibody targeting cell surface TACE/ADAM17-cleaved Amphiregulin in breast cancer. PMID: 34877472

Targeted delivery of TAPI-1 via biomimetic nanoparticles ameliorates post-infarct left ventricle function and remodelling. PMID: 40038918

Polymorphisms of the tumor necrosis factor-alpha (TNF) and the TNF-alpha converting enzyme (TACE/ADAM17) genes in relation to cardiovascular mortality: the AtheroGene study. PMID: 18600307

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