武汉艾必赛生物有限公司推荐WNV NS1 Recombinant Protein (N-His),精品蛋白

链接：https://www.abinscience.cn/product/78/41043.html

名称：WNV NS1 Recombinant Protein (N-His)

货号：VK554012

品牌：abinScience

表达系统：E. coli

Accession号：Q9Q6P4

蛋白长度：Arg963-Ala1143

应用：ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

种属：West Nile virus (WNV)

性质：Recombinant

内毒素水平：Please contact with the lab for this information.

纯度：>90% as determined by SDS-PAGE.

预测分子量：22.72 kDa

状态：Lyophilized

用途范围：仅用于科研

储存：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

 

产品介绍：WNV NS1 Recombinant Protein (N-His, RUO)｜VK554012 是艾必赛生物（abinScience）推出的西尼罗河病毒（West Nile virus, WNV）非结构蛋白 NS1 重组抗原，由 E. coli 系统表达，带 N 端 6×His 标签，覆盖 Arg963–Ala1143 区段，可作为 WNV 血清学检测、NS1 抗体开发及病毒免疫逃逸机制研究的阳性/质控参照工具。该蛋白经 IMAC 纯化，纯度 >90%（SDS-PAGE），以冻干粉形式保存于 PBS pH 7.4（含 1 mM EDTA、4% Trehalose、1% Mannitol） 中；频繁使用 2–8°C，长期建议 -20°C 至 -80°C（自收货日起 ≤12 个月）避反复冻融。推荐应用于 ELISA、Western blot、免疫原、SDS-PAGE。（RUO，仅限科研/非临床用途）

西尼罗河病毒（WNV） 属黄病毒科黄病毒属，为有囊膜单股正链 RNA 病毒，主要通过蚊虫叮咬传播，多数感染无症状，部分可发展为发热、脑膜炎或脑炎，老年及免疫低下人群风险更高。病毒复制过程中产生多种结构与非结构蛋白，其中 NS1 是分泌型二聚体/膜相关糖蛋白，不参与病毒颗粒组装，但可调控复制复合体、干扰补体通路与宿主天然免疫，并在感染早期释放入血，是 WNV 诊断试剂与中和抗体评价的重要靶标。

 

 

 

产品购买联系方式：027-87433958/17302791434

邮箱：info@abinscience.com

参考文献：

Flavivirus NS1 Triggers Tissue-Specific Vascular Endothelial Dysfunction Reflecting Disease Tropism. PMID: 30726741

Role of NS1 and TLR3 in Pathogenesis and Immunity of WNV. PMID: 31277274

Flavivirus NS1-triggered endothelial dysfunction promotes virus dissemination. PMID: Update in:

A species-independent lateral flow microarray immunoassay to detect WNV and USUV NS1-specific antibodies in serum. PMID: 38261918

A broadly protective antibody that targets the flavivirus NS1 protein. PMID: 33414219

Roles of NS1 Protein in Flavivirus Pathogenesis. PMID: 38110348

Differential properties of NS1 glycoproteins in West Nile and Usutu viruses. PMID: 42054312

Flavivirus NS1: a multifaceted enigmatic viral protein. PMID: 27473856

Emerging viral infections: role of flavivirus NS1-mediated rewiring of PRR signaling. PMID: 42421497

The Role of NS1 Protein in the Diagnosis of Flavivirus Infections. PMID: 36851784

Dengue Virus Non-Structural Protein 5. PMID: 28441781

Levels of Circulating NS1 Impact West Nile Virus Spread to the Brain. PMID: 34346770

N-linked glycosylation of NS1 protein modulates progeny virion assembly in orthoflaviviruses. PMID: 42424390

Flavivirus NS1 and Its Potential in Vaccine Development. PMID: 34207516

Coatomer protein complex I is required for efficient secretion of dengue virus non-structural protein 1. PMID: 40838750

Japanese encephalitis virus NS1 and NS1' protein disrupts the blood-brain barrier through macrophage migration inhibitory factor-mediated autophagy. PMID: 38591880

Human Monoclonal Antibodies against NS1 Protein Protect against Lethal West Nile Virus Infection. PMID: 34634945

Replication-Defective West Nile Virus with NS1 Deletion as a New Vaccine Platform for Flavivirus. PMID: 31189715

Antibody ratios against NS1 antigens of tick-borne encephalitis and West Nile viruses support differential flavivirus serology in dogs. PMID: 35704505

Diagnosing arthropod-borne flaviviruses: non-structural protein 1 (NS1) as a biomarker. PMID: 38135616

Flavivirus enzymes and their inhibitors. PMID: 34696835

Humoral and cellular responses to a tetravalent dengue vaccine (TAK-003) in adults from a dengue non-endemic region: An open-label phase 2 trial. PMID: 41722532

Self-association features of NS1 proteins from different flaviviruses. PMID: 35662566

Tracking WNV transmission with a combined dog and wild boar surveillance system. PMID: 40169736

Identification of multiple arbovirus infections/exposure in Northeastern Brazil using a multiplex microsphere immunoassay. PMID: 42060779

West Nile Virus NS1 Antagonizes Interferon Beta Production by Targeting RIG-I and MDA5. PMID: 28659477

Linear epitope identification of monoclonal antibodies against the duck Tembusu virus NS1. PMID: 37499611

Structural basis of Flavivirus NS1 assembly and antibody recognition. PMID: 24594604

Assessing West Nile virus (WNV) and Usutu virus (USUV) exposure in bird ringers in the Netherlands: a high-risk group for WNV and USUV infection? PMID: 37363259

Structural basis for antibody inhibition of flavivirus NS1-triggered endothelial dysfunction. PMID: 33414220

Innate Immune Evasion Mediated by Flaviviridae Non-Structural Proteins. PMID: 28991176

Secretory pathways and multiple functions of nonstructural protein 1 in flavivirus infection. PMID: 37520540

NS1' colocalizes with NS1 and can substitute for NS1 in West Nile virus replication. PMID: 23760245

Virulence determinants of West Nile virus: how can these be used for vaccine design? PMID: 28919920

Monitoring Anti-NS1 Antibodies in West Nile Virus-Infected and Vaccinated Horses. PMID: 30356362

Secretion of flaviviral non-structural protein NS1: from diagnosis to pathogenesis. PMID: 17319166

NS1 protein secretion during the acute phase of West Nile virus infection. PMID: 16254328

Linear and Continuous Flavivirus Epitopes From Naturally Infected Humans. PMID: 34458161

Selection and Characterization of Anti-Dengue NS1 Single Domain Antibodies. PMID: 30591706

Tick-Borne Encephalitis Virus Surveillance-Vaccination- and Infection-Induced Seroprevalences in Western Austria 2024. PMID: 39660431

Molecular Determinants of Tissue Specificity of Flavivirus Nonstructural Protein 1 Interaction with Endothelial Cells. PMID: 36106873

Making sense of flavivirus non-strctural protein 1 in innate immune evasion and inducing tissue-specific damage. PMID: 37716670

Production of recombinant NS1 protein and its possible use in encephalitic flavivirus differential diagnosis. PMID: 30125621

Development of a quantitative NS1 antigen enzyme-linked immunosorbent assay (ELISA) for Zika virus detection using a novel virus-specific mAb. PMID: 38291109

Dengue Virus NS1 Disrupts the Endothelial Glycocalyx, Leading to Hyperpermeability. PMID: 27416066

Role of NS1 antibodies in the pathogenesis of acute secondary dengue infection. PMID: 30531923

mTOR Signalling in Arbovirus Infections: Molecular Mechanisms and Therapeutic Opportunities. PMID: 40317563

Comprehensive mapping of West Nile virus (WNV)- and Japanese encephalitis virus serocomplex-specific linear B-cell epitopes from WNV non-structural protein 1. PMID: 21940411

 

 

 

详情请咨询 abinScience 亚洲区官方子公司 —— 武汉艾必赛生物技术有限公司
官方网址：【中文】https://www.abinscience.cn

【英文】https://www.abinscience.com

武汉艾必赛生物技术有限公司成立于 2023 年，是 abinScience 在亚洲地区设立的官方全资子公司，全面负责 abinScience 品牌在亚太市场的科研试剂推广、销售及技术支持工作。
依托严格的产品研发体系和国际化的质量管理标准，武汉艾必赛与 AtaGenix、ProteoGenix 等知名品牌保持长期战略合作，现已构建起涵盖抗体、重组蛋白、工具酶、试剂盒、实验耗材在内的多品类供应体系，面向区域内科研机构、高校实验室与生物医药企业，提供稳定、高效、可信赖的产品与服务。
核心业务覆盖：
✅ 抗体产品（单抗、多抗、重组抗体等）
✅ 蛋白与多肽试剂（标签蛋白、功能蛋白等）
✅ 分子与细胞实验相关耗材
✅ 定制化研发服务（蛋白表达、抗体定制、亲和力成熟等）
✅ 科研供应链整合与项目配套支持
武汉艾必赛始终秉持“Empowering Bioscience Discovery”的理念，为亚太地区的生命科学研究持续注入高质量动能。