链接：https://www.biomart.cn/infosupply/113594534.htm
名称：Anti-Human CD257/BAFF/TNFSF13B Antibody (BlySmAb-1.1)
Accession号：Q9Y275
货号：HV212107
种属反应性：Human
宿主：Human
形式：Liquid
纯度：>95% as determined by SDS-PAGE.
克隆性：Monoclonal
同种型：IgG1, lambda
应用：FCM
靶点：BAFF, ZTNF4, BLYS, Tumor necrosis factor ligand superfamily member 13B, Dendritic cell-derived TNF-like molecule, TALL-1, TNF- and APOL-related leukocyte expressed ligand 1, BLyS, B lymphocyte stimulator, TNFSF13B, CD257, TNFSF20, TALL1, B-cell-activating factor, Neutrokine-alpha
用途范围：仅用于科研
储存：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
产品介绍：Anti-Human CD257/BAFF/TNFSF13B Antibody (BlySmAb-1.1) 是武汉艾必赛生物科技有限公司推出的一款高特异性、高灵敏度的人源单克隆抗体。该抗体靶向人B细胞激活因子（BAFF/TNFSF13B/CD257），该靶点是B细胞存活、增殖与成熟的关键调节因子，在B细胞介导的体液免疫及自身免疫性疾病发生发展中发挥核心作用。本品克隆号为BlySmAb-1.1，宿主为人源，同种型为IgG1, lambda，通过Protein A/G从细胞培养上清中纯化，纯度经SDS-PAGE检测超过95%，经严格验证适用于流式细胞术（FCM）。其完整人源抗体序列赋予其低免疫原性、高亲和力等特性，是研究B细胞发育、自身免疫性疾病（如系统性红斑狼疮）、相关肿瘤免疫及开发靶向疗法研究的理想工具试剂。
产品购买联系方式：027-87433958/17302791434
邮箱：info@abinscience.com
参考文献：
BAFF and BAFF-Receptor in B Cell Selection and Survival. PMID: 30349534
BAFF AND APRIL: a tutorial on B cell survival. PMID: 12427767
Neutrophil Extracellular Traps Activate Proinflammatory Functions of Human Neutrophils. PMID: 34168641
Targeting BAFF and APRIL in systemic lupus erythematosus and other antibody-associated diseases. PMID: 28215100
An IL-1β-driven neutrophil-stromal cell axis fosters a BAFF-rich protumor microenvironment in individuals with multiple myeloma. PMID: 38600356 BAFF-R. PMID: 12456020
B cells in the pathogenesis of primary Sj?gren syndrome. PMID: 29416129
Genetics of Sj?gren's syndrome. PMID: 28476436
Single-Cell Immune Profiling Reveals Neutrophils Promote Myasthenia Gravis Exacerbation Through BAFF Secretion. PMID: 40995750
Biomarkers for Sj?gren's syndrome. PMID: 29460647
CD256 can be found in antibody-mediated renal allograft rejection tissues. PMID: 22783569
BAFF signaling in health and disease. PMID: 34352467
BAFF signaling in B cell metabolism. PMID: 34174517
B Cells, Antibodies, and More. PMID: 26700440
The role of B cell-activating factor system in autoimmune diseases: mechanisms, disease implications, and therapeutic advances. PMID: 40547016
Biologic markers of chronic GVHD. PMID: 23872737
Targeting BAFF in autoimmunity. PMID: 20970975
BAFF-ling autoantibodies. PMID: 24270413
Pathogenesis of Sj?gren's syndrome. PMID: 19568172
Peripheral B lymphocyte tolerance. PMID: 15477728
SLE Conundrums. PMID: 20061717
NF-kappaB and rheumatic diseases. PMID: 17214582
Immune cell composition and inflammatory profile of human peri-implantitis and periodontitis lesions. PMID: 38616555
Editorial overview: BAFF family ligands and receptors - a license to live. PMID: 34503766
BAFF receptor polymorphisms and deficiency in humans. PMID: 34311146
Ezh2 Ameliorates Osteoarthritis by Activating TNFSF13B. PMID: 31910305
A role for BLyS in tissue inflammation? PMID: 12687529
The uncertain glory of APRIL. PMID: 14502235
BLyS and B cell autoimmunity. PMID: 12408045
B-cell regulation and its application to transplantation. PMID: 23909582
Innate control of B cell responses. PMID: 21419699
Signaling pathways for B cell-activating factor (BAFF) and a proliferation-inducing ligand (APRIL) in human placenta. PMID: 18403603
Immunomodulators for allergic respiratory disorders. PMID: 18269921
BAFF in autoimmune kidney diseases: pathogenic pathways, biomarker potential, and therapeutic horizons. PMID: 41236208
The role of BAFF in the progression of rheumatoid arthritis. PMID: 26198030
Subcutaneous belimumab in the treatment of systemic lupus erythematosus. PMID: 30105936
B cell-targeted therapies in Sj?gren's syndrome. PMID: 19671451
Exploring immunological alterations of B cells in peripheral immunity via single-cell RNA sequencing: insights into primary membranous nephropathy. PMID: 40904455
Function, occurrence and inhibition of different forms of BAFF. PMID: 34182216
Evolving BAFF targeted therapies for preventing acute myocardial infarctions and ischemic strokes. PMID: 31939689
Molecular basis of common variable immunodeficiency. PMID: 16630927
In this issue: Antibodies in pathogenesis and management of diseases. PMID: 28215101
SLE--systemic lupus erythematosus: a BLySful, yet BAFFling, disorder. PMID: 12723979
Systemic lupus erythematosus and its ABCs (APRIL/BLyS complexes). PMID: 20441604
The BAFFling effects of rituximab in lupus: danger ahead? PMID: 26888554
The B cell: a new therapeutic target in rheumatoid arthritis and other autoimmune diseases. PMID: 15474382
B cell therapy in ANCA-associated vasculitis: current and emerging treatment options. PMID: 30108367
Telitacicept for lupus nephritis with BAFF and APRIL double positivity in children: a case report. PMID: 40420262
Positive and negative cooperativity of TNF and Interferon-γ in regulating synovial fibroblast function and B cell survival in fibroblast/B cell co-cultures. PMID: 31964950
Expression of TNF-superfamily members BAFF and APRIL in breast cancer: immunohistochemical study in 52 invasive ductal breast carcinomas. PMID: 18366696
BAFF-driven NLRP3 inflammasome activation in B cells. PMID: 33004801
The function of BAFF on T helper cells in autoimmunity. PMID: 24411564
详情请咨询 abinScience 亚洲区官方子公司 —— 武汉艾必赛生物技术有限公司
武汉艾必赛生物技术有限公司成立于 2023 年，是 abinScience 在亚洲地区设立的官方全资子公司，全面负责 abinScience 品牌在亚太市场的科研试剂推广、销售及技术支持工作。
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核心业务覆盖：
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? 蛋白与多肽试剂（标签蛋白、功能蛋白等）
? 分子与细胞实验相关耗材
? 定制化研发服务（蛋白表达、抗体定制、亲和力成熟等）
? 科研供应链整合与项目配套支持
武汉艾必赛始终秉持“Empowering Bioscience Discovery”的理念，为亚太地区的生命科学研究持续注入高质量动能。
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