链接：https://www.abinscience.cn/product/78/56088.html
名称：Feline IL11RA Recombinant Protein (C-Fc)
货号：FC604021
表达系统：Mammalian cells
Accession号：XP_006939298.2
蛋白长度：Cys26-Ala367
应用：ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
种属：Felis catus (Cat)
性质：Recombinant
内毒素水平：Please contact with the lab for this information.
纯度：>90% as determined by SDS-PAGE.
预测分子量：65.58 kDa
状态：Lyophilized
用途范围：仅用于科研
储存：Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
产品介绍：Feline IL11RA Recombinant Protein (C-Fc)（货号 FC604021）是艾必赛生物（abinScience）推出的猫源（Felis catus）重组白细胞介素?11 受体 α 亚基，C 端融合 hIgG1 Fc 标签，序列对应 XP_006939298.2、Cys26–Ala367，可作为猫 IL?11/IL11RA 信号研究、抗 IL?11 疗法兽医转化、ELISA/WB/免疫原 等应用的蛋白标准/捕获试剂。该蛋白在哺乳动物细胞中表达，折叠与糖基化更接近天然构象，经亲和纯化，纯度 >90%（SDS?PAGE），以冻干粉**形式保存于 PBS pH 7.4 + 1 mM EDTA + 4% 海藻糖 + 1% 甘露醇 中，无菌水重溶；频繁使用 2–8°C，长期建议 -20 至 -80°C 避反复冻融（自收货日起 ≤12 个月）。（RUO，仅限科研/非临床用途）
IL?11/IL11RA 通路 通过与 gp130 共受体形成信号复合体激活 JAK/STAT，在纤维化（心肌、肺、肾）、骨代谢、胎盘发育等过程中起关键作用；近年抗 IL?11 中和抗体（如 Linerixibat 之外的在研管线）在心肌纤维化领域显示出治疗潜力。FC604021 提供猫源 IL11RA 胞外区 + Fc 的重组形式，预测分子量 ~65.6 kDa，Bioactivity 在验证中，配套同系列 C?His 版本可选，适合搭建猫慢性肾病/心肌病等相关纤维化机制的临床前/兽医研究模型，是填补"模式物种（猫）—纤维化靶点"试剂空白的科研级蛋白。
产品购买联系方式：027-87433958/17302791434
邮箱：info@abinscience.com
参考文献：
Prognostic significance of IL11RA and its methylation in lung adenocarcinoma. PMID: 40530134
IL-11 is a crucial determinant of cardiovascular fibrosis. PMID: 29160304
Xenopus laevis il11ra.L is an experimentally proven interleukin-11 receptor component that is required for tadpole tail regeneration. PMID: 35115663
Inhibiting IL11RA to mitigate hepatic metastasis in skin cutaneous melanoma: Comprehensive insights from in vitro and in vivo investigations. PMID: 38468436
Interleukin-11. PMID: 7532057
Interleukin 11 therapy causes acute left ventricular dysfunction. PMID: 39383190
Enhancing antitumor immunity and achieving tumor eradication with IL11RA mRNA immunotherapy. PMID: 38718659
Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis. PMID: 31078624
IL11RA-related Crouzon-like autosomal recessive craniosynostosis in 10 new patients: Resemblances and differences. PMID: 29926465
Adipokine IL-11/IL-11Ra constrains sphingolipid metabolism to limit the thermogenic capacity of beige adipocytes. PMID: 42140185
IL-11/IL11RA receptor mediated signaling: a web accessible knowledgebase. PMID: 23631681
Mutations in the interleukin receptor IL11RA cause autosomal recessive Crouzon-like craniosynostosis. PMID: 24498618
Adult mice with targeted mutation of the interleukin-11 receptor (IL11Ra) display normal hematopoiesis. PMID: 9310465
Interleukin-11 drives human and mouse alcohol-related liver disease. PMID: 35365572
Genetic Insights Into Craniosynostosis: Identification of Novel IL11RA Variants in Chinese Pediatric Patients. PMID: 40353334
Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease. PMID: 36470928
Urinary proteomics identifies distinct immunological profiles of sepsis associated AKI sub-phenotypes. PMID: 39695715
The Emerging Role of Interleukin-(IL)-11/IL-11R in Bone Metabolism and Homeostasis: From Cytokine to Osteokine. PMID: 37199584
Multiple craniosynostosis and facial dysmorphisms with homozygous IL11RA variant caused by maternal uniparental isodisomy of chromosome 9. PMID: 32277509
Targeting carcinoma-associated mesothelial cells with antibody-drug conjugates in ovarian carcinomatosis. PMID: 37555348
IL11 modulates MMP12 expression and cancer cell metastasis via IL11RA/IL6ST-PI3K/Akt/NF-kappaB pathway in lung cancer. PMID: 42276992
Identification of IL11RA and MELK amplification in gastric cancer by comprehensive genomic profiling of gastric cancer cell lines. PMID: 27920471
Evolution of the phenotype of craniosynostosis with dental anomalies syndrome and report of IL11RA variant population frequencies in a Crouzon-like autosomal recessive syndrome. PMID: 30811827
Exploring the relationship between the interleukin family and lung adenocarcinoma through Mendelian randomization and RNA sequencing analysis. PMID: 39264458
Interleukin-11 promotes lung adenocarcinoma tumourigenesis and immune evasion. PMID: 40673604
Identification of SARS2, PKN1, and IL11RA as causally-associated genes for patients with gastric cancer via immune cell activity: A multi-omics Mendelian randomization study integrating GWAS, eQTL, and pQTL data. PMID: 41289788
The outcome of targeted NGS screening in patients with syndromic forms of sagittal and pansynostosis - IL11RA is an emerging core-gene for pansynostosis. PMID: 35331937
Genes involved in implantation. PMID: 11545164
Single-cell deconvolution algorithms analysis unveils autocrine IL11-mediated resistance to docetaxel in prostate cancer via activation of the JAK1/STAT4 pathway. PMID: 38429845
Update on development of interleukin-11. PMID: 9371993
Biallelic IL11RA Variants in Twin Brothers with Complex Craniosynostosis: Identification of a Novel Variant and Postulation of Epigenetic Differences. PMID: 41563703
Therapeutic opportunities for senolysis in cardiovascular disease. PMID: 35015342
Dapagliflozin Interrupts Pro-Fibroinflammatory Interleukin 11-Tenascin C Mutual Reinforcement in Fibroblasts by Antagonizing Interleukin-11 Receptor Subunit Alpha. PMID: 40583258
The biology of interleukin 11. PMID: 8401258
详情请咨询 abinScience 亚洲区官方子公司 —— 武汉艾必赛生物技术有限公司
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武汉艾必赛生物技术有限公司成立于 2023 年，是 abinScience 在亚洲地区设立的官方全资子公司，全面负责 abinScience 品牌在亚太市场的科研试剂推广、销售及技术支持工作。
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核心业务覆盖：
? 抗体产品（单抗、多抗、重组抗体等）
? 蛋白与多肽试剂（标签蛋白、功能蛋白等）
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武汉艾必赛始终秉持“Empowering Bioscience Discovery”的理念，为亚太地区的生命科学研究持续注入高质量动能。
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