链接：https://www.abinscience.cn/product/78/56089.html
名称：Canine IL11RA Recombinant Protein (C-His)
货号：CC604011
表达系统：Mammalian cells
Accession号：XP_038537937.1
蛋白长度：Val23-Leu363
应用：ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
种属：Canis lupus familiaris (Dog)
性质：Recombinant
内毒素水平：Please contact with the lab for this information.
纯度：>90% as determined by SDS-PAGE.
预测分子量 39.91 kDa
状态：Lyophilized
用途范围：仅用于科研
储存：Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
产品介绍：Canine IL11RA Recombinant Protein (C-His)（CC604011） 是艾必赛生物（abinScience）推出的犬源白细胞介素-11 受体α亚基（IL11RA）重组蛋白，C 端融合 His 标签，表达区间 Val23–Leu363，由哺乳动物细胞表达，适用于ELISA、Western Blot、SDS-PAGE 及作为免疫原等应用（生物活性正在验证中）。该蛋白以冻干粉形式提供，冻干前溶液为 PBS pH 7.4，含 1 mM EDTA、4% 海藻糖、1% 甘露醇；纯度 >90%（SDS-PAGE 测定），预测分子量 39.91 kDa，需用无菌水重溶。短期 2–8°C 存放，长期建议 -20 至 -80°C 避反复冻融保存（自收货日起 ≤12 个月）。（RUO，仅限科研/非临床用途）
IL11RA 是 IL-11 的特异性受体亚基，归属于 I 型细胞因子受体家族；IL-11 与其结合后招募 gp130 共同信号亚基，形成功能性受体复合物并激活 JAK-STAT 等信号通路，广泛参与造血支持、巨核细胞分化与血小板生成、骨代谢调节、肠道上皮保护、组织修复与胚胎发育等生物学过程。近年研究进一步表明，IL11RA 在成纤维细胞、平滑肌细胞、肝/胰腺星状细胞等多种基质细胞中高表达，IL-11 信号通路已被确认为纤维化（尤其是心肌与组织纤维化）的关键驱动因素之一，使其成为抗炎、抗纤维化药物研发的重要靶点。本品为大动物（犬）模型的 IL-11/IL11RA 通路研究、抗体/小分子药物筛选及体外受体-配体互作实验提供天然构象更接近生理状态的犬源蛋白工具。
产品购买联系方式：027-87433958/17302791434
邮箱：info@abinscience.com
参考文献：
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The canine as an animal model of human aging and dementia. PMID: 8744407
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Canine Parvovirus 2 in Free-Living Wild Mammals from Southern Brazil. PMID: 37270203
Canine tactical field care part three - thoracic and abdominal trauma. PMID: 20306416
Advanced approaches for the diagnosis and chemoprevention of canine vector-borne pathogens and parasites-Implications for the Asia-Pacific region and beyond. PMID: 36948727
Sodium-glucose co-transporter 2 inhibitors: Prospects for canine myxomatous mitral valve disease and finding the "right drug" and the "right dose" for dogs. PMID: 40240174
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Pathology of myxomatous mitral valve disease in the dog. PMID: 22386587
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A comprehensive review on past, present and future aspects of canine theileriosis. PMID: 30385396
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[Canine Leptospirosis]. PMID: 21012485
Evolution of haematopoietic cell transplantation for canine blood disorders and a platform for solid organ transplantation. PMID: 34390541
Comparing alternatives to canine rectal thermometry at the axillary, auricular and ocular locations. PMID: 32042649
Military veterans and canine assistance for post-traumatic stress disorder: A narrative review of the literature. PMID: 27179660
Canine Circovirus Suppresses the Type I Interferon Response and Protein Expression but Promotes CPV-2 Replication. PMID: 35742826
Detection of canine parvovirus type 2c (CPV-2c) in Palestine. PMID: 38865411
Identification and characterization of cancer stem cells in canine mammary tumors. PMID: 27993142
Picture This: Management of Canine Pyotraumatic Dermatitis (a.k.a., Hot Spot). PMID: 29889965
A Unique Canine Comfort Therapy Program for Child Maltreatment Cases. PMID: 37890064
Canine models of gene-modified hematopoiesis. PMID: 19110637
Canine cruciate ligament ruptures: Implications for financial costs and human health. PMID: 32574421
Exploring canine olfactory generalization using odor profile fractions from native crude oils. PMID: 39418316
Canine trypanosomiasis in an endemic Costa Rican community: Demonstration of the active infection cycle. PMID: 31303214
Prevalence and Clinical Impacts of Canine Herpesvirus-1 (CHV-1) in Dogs: A Review of Reproductive Effects and Ocular Lesions. PMID: 41259018
Metagenomic characterisation of canine skin reveals a core healthy skin microbiome. PMID: 39209855
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Risk factors for canine magnesium ammonium phosphate urolithiasis associated with bacterial infection. PMID: 35088952
Canine olfactory detection of a vectored phytobacterial pathogen, Liberibacter asiaticus, and integration with disease control. PMID: 32015115
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A map of canine sequence variation relative to a Greenland wolf outgroup. PMID: 39088040
Development of a method for the isolation and culture of astrocytes from the canine cerebral cortex. PMID: 35007653
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The bacteriostatic effect of erythritol on canine periodontal disease-related bacteria. PMID: 35575772
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