链接：https://www.abinscience.cn/product/5414/56442.html
名称：Anti-SFTSV Antibody Pair Set
货号：VK662908
应用：ELISA
偶联物：Detection: Biotin
经测试应用：S-ELISA
状态：Liquid
用途范围：仅用于科研
储存：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
产品介绍：Anti-SFTSV Antibody Pair Set (VK662908) 是艾必赛生物（abinScience）推出的SFTSV 抗体对套装，包含 Capture 与 Biotin 标记的 Detection 两株抗体，专为 Sandwich ELISA（夹心 ELISA） 定量检测发热伴血小板减少综合征病毒（SFTSV）而设计，可作为 SFTSV 血清学筛查、病毒载量测定及疫苗/药物评价中的标准检测试剂对照。该抗体对经配对优化，检测范围 9.38–600 ng/mL，灵敏度低至 2.21 ng/mL，规格为 Capture 100 μg & Detection 50 μL（可供 ≥1 块 96 孔板）；Capture 与 Detection 抗体均以液体形式保存于 0.01M PBS, pH 7.4，Detection 抗体中含 50% 甘油；频繁使用 2–8°C，长期建议 -20 至 -80°C 避反复冻融（For Research Use Only，仅限科研/非临床用途）。
SFTSV（Severe Fever with Thrombocytopenia Syndrome Virus，发热伴血小板减少综合征病毒）是 2009 年在我国首次发现的蜱传白纤病毒科班达病毒属病原（ICTV 2019 年命名为 Bandavirus dabieense），基因组为分节段负链 RNA（L/M/S 三节段），经长角血蜱叮咬传播，也可通过接触患者血液/分泌物人际传播；感染后出现持续高热、血小板减少、白细胞下降、胃肠症状，重症可进展为多器官衰竭，病死率可达约 30%，已被 WHO 列为十大优先防控传染病之一。病毒表面由 Gn 与 Gc 两个刺突糖蛋白组成包膜突起——Gn 负责受体识别与附着，Gc 介导内体膜融合，二者是中和抗体与疫苗研发的核心靶标，其中 Gn 更是主要抗原表位富集区。
产品购买联系方式：027-87433958/17302791434
邮箱：info@abinscience.com
参考文献：
Current Progress of Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) Vaccine Development. PMID: 38257828
Bunyavirus SFTSV exploits autophagic flux for viral assembly and egress. PMID: 34747299
Genome-wide CRISPR screening identifies LRP1 as an entry factor for SFTSV. PMID: 40301361
SFTSV utilizes AXL/GAS6 for entry via PI3K-PLC-dependent macropinocytosis activated by AXL-kinase. PMID: 40853130
Bunyavirus SFTSV NSs utilizes autophagy to escape the antiviral innate immune response. PMID: 38762760
Bunyavirus SFTSV nucleoprotein exploits TUFM-mediated mitophagy to impair antiviral innate immunity. PMID: 39189526
Bispecific antibodies targeting two glycoproteins on SFTSV exhibit synergistic neutralization and protection in a mouse model. PMID: 38830098
Antibody Development Strategies for SFTSV: From Hybridoma to Emerging Technologies. PMID: 40991429
SFTSV infection in rodents and their ectoparasitic chiggers. PMID: 36037170
SFTSV induces liver ferroptosis through m6A-related ferritinophagy. PMID: 40340535
hnRNPA2B1 recognizes RNA virus SFTSV infection through mitochondrial DNA. PMID: 40689679
SFTSV NSs degrades SAFA via autophagy to suppress SAFA-dependent antiviral response. PMID: 40460159
Molecular mechanism and structure-guided humanization of a broadly neutralizing antibody against SFTSV. PMID: 39321193
Immune Cells at the Frontline of SFTSV Infection. PMID: 41742453
SFTSV nucleoprotein mediates DNA sensor cGAS degradation to suppress cGAS-dependent antiviral responses. PMID: 38712963
sVEGFR1 up-regulation via EGR1 impairs vascular repair in SFTSV-induced hemorrhage. PMID: 40789964
SFTSV NSs interacts with AGO2 to regulate the RNAi pathway for viral replication. PMID: 40013801
Age-associated immune dysregulation and B cell dysfunction drive severe outcomes in SFTSV infection. PMID: 40794649
A Focus on the Mechanisms of Alteration in Host Lymphocyte Level Following Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) Infection. PMID: 41031180
SFTSV Infection Induced Interleukin-1beta Secretion Through NLRP3 Inflammasome Activation. PMID: 33708197
Identification and characterization of three monoclonal antibodies targeting the SFTSV glycoprotein and displaying a broad spectrum recognition of SFTSV-related viruses. PMID: 38848311
SFTSV Gn-Head mRNA vaccine confers efficient protection against lethal viral challenge. PMID: 37909776
Overview of the immunological mechanism underlying severe fever with thrombocytopenia syndrome (Review). PMID: 35856413
SFTSV Prevalence in Ticks and Livestock in an SFTSV-Endemic Area in Central China. PMID: 41011843
SFTSV-encoded microRNA-like small RNA as prognostic biomarkers in severe fever with thrombocytopenia syndrome. PMID: 41498237
CCR2 is a host entry receptor for severe fever with thrombocytopenia syndrome virus. PMID: 37531422
A broadly protective antibody targeting glycoprotein Gn inhibits severe fever with thrombocytopenia syndrome virus infection. PMID: 39147753
The SFTSV Nonstructural Proteins Induce Autophagy to Promote Viral Replication via Interaction with Vimentin. PMID: 37039677
Taurolithocholic acid protects against viral haemorrhagic fever via inhibition of ferroptosis. PMID: 39294459
Genetic and pathogenic diversity of severe fever with thrombocytopenia syndrome virus (SFTSV) in South Korea. PMID: 31877113
Bandavirus dabieense: A review of epidemiology, clinical characteristics, pathophysiology, treatment and prevention. PMID: 40519175
Investigation into the Pancreatic Pathogenesis of SFTSV across Multiple Levels. PMID: 41090515
SFTSV-Nluc: a useful tool for studying SFTSV biology and countermeasures. PMID: 38194743
Novel SFTSV Phylogeny Reveals New Reassortment Events and Migration Routes. PMID: 32960400
The therapeutic potential of mRNA-encoded SFTSV human monoclonal antibody encapsulated lipid nanoparticle in vivo. PMID: 40228669
Experimental Infection of Ticks with SFTSV. PMID: 39671033
Targeting the lethal weakness of SFTSV: Latest advances in antiviral strategies and immune prevention. PMID: 41940348
Reactivation of Epstein-Barr virus in SFTSV infected patients. PMID: 38073887
SFTSV NSs Sequesters the Complex of SFTSV NP-SAFA to Suppress SAFA Mediated Immune Response. PMID: 41439738
Advances in research on severe fever with thrombocytopenia syndrome virus. PMID: 40771693
Severe fever with thrombocytopenia syndrome and its pathogen SFTSV. PMID: 25498868
Rapid inactivation of Dabie bandavirus (SFTSV) by irradiation with deep-ultraviolet light-emitting diode. PMID: 35246855
The hnRNP A2B1 is important for the replication of SFTSV and other RNA viruses. PMID: 39166862
The Cap-Snatching SFTSV Endonuclease Domain Is an Antiviral Target. PMID: 31914382
Potent immunogenicity and neutralization of recombinant adeno-associated virus expressing the glycoprotein of severe fever with thrombocytopenia virus. PMID: 38143087
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武汉艾必赛生物技术有限公司成立于 2023 年，是 abinScience 在亚洲地区设立的官方全资子公司，全面负责 abinScience 品牌在亚太市场的科研试剂推广、销售及技术支持工作。
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