（可申请试用）武汉艾必赛生物有限公司推荐Anti-HMPV G/Major surface glycoprotein G Polyclonal Antibody,精品抗体

链接：https://www.abinscience.cn/product/34/12959.html

名称：Anti-HMPV G/Major surface glycoprotein G Polyclonal Antibody

货号：VK673014

种属反应性：Human metapneumovirus (HMPV)

应用：ELISA, IHC, WB

宿主：Rabbit

克隆类型：Polyclonal

同种型：IgG

免疫原：E. coli - derived recombinant HMPV G/Major surface glycoprotein G (Asn52-Asn219).

靶标：Major surface glycoprotein G, Attachment glycoprotein G, Membrane-bound glycoprotein, mG, G

纯化方式：Purified by antigen affinity column.

Accession号：Q6WB94

状态：Liquid

用途范围：仅用于科研

储存：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

 

产品介绍：Anti-HMPV G/Major surface glycoprotein G Polyclonal Antibody (VK673014, RUO) 是艾必赛生物（abinScience）推出的兔源多克隆抗体（Rabbit IgG），靶向人偏肺病毒（Human metapneumovirus, hMPV）的表面吸附糖蛋白 G。免疫原为 E. coli 表达的重组 HMPV G 蛋白（Asn52-Asn219，CAN97-83 株），经抗原亲和柱纯化，以液体形式保存在 0.01M PBS, pH 7.4，含 50% 甘油、0.05% Proclin 300 中；适用于 ELISA、IHC、WB。频繁使用 2–8°C 保存，长期建议 -20°C 至 -80°C（自收货日起 ≤12 个月）避反复冻融。（RUO，仅限科研/非临床用途）

人偏肺病毒（hMPV） 属肺病毒科（Pneumoviridae）偏肺病毒属，为有囊膜单股负链 RNA 病毒，2001 年首次被鉴定，是婴幼儿、老年人及免疫低下人群急性呼吸道感染的重要病原之一，临床可表现为咳嗽、发热、喘息，重症可进展为毛细支气管炎或肺炎，目前尚无获批疫苗与特效抗病毒药。病毒包膜上主要有 F 与 G 两种糖蛋白：G 蛋白（约 23 kDa） 通过与宿主细胞表面糖胺聚糖（GAGs）结合介导病毒附着，但不具备神经氨酸酶与血凝活性；此外，G 蛋白可结合胞内病毒 RNA 感受器 RIG-I，阻断 RIG-I–MAVS 线粒体信号复合体形成，抑制 I 型干扰素与炎性因子产生，从而帮助病毒逃逸天然免疫。因此 G 蛋白既是 hMPV 诊断抗体、阻断实验与致病机制研究的关键靶标，也是疫苗/免疫调节研究的重要参照。

 

 

目前产品可申请货号试用：

 

 

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参考文献：

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Profiling of hMPV F-specific antibodies isolated from human memory B cells. PMID: 35538099

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Minireview: Designing next generation human metapneumovirus (HMPV) vaccine. PMID: 40321790

The Silent War of hMPV: Viral Interference with Host Immunity. PMID: 42737877

Non-Coding RNAs and Their Role in Respiratory Syncytial Virus (RSV) and Human Metapneumovirus (hMPV) Infections. PMID: 32245206

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Human metapneumovirus (hMPV): the virus who came with the common cold. PMID: 40794271

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Probenecid Inhibits Human Metapneumovirus (HMPV) Replication In Vitro and in BALB/c Mice. PMID: 39066249

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Human Metapneumovirus (hMPV) Infection and MPV467 Treatment in Immunocompromised Cotton Rats Sigmodon hispidus. PMID: 36851691

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Potent cross-neutralization of respiratory syncytial virus and human metapneumovirus through a structurally conserved antibody recognition mode. PMID: 37516111

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Epidemiology of HMPV and Other Respiratory Viral Infections Among Outpatients, 2016-2022. PMID: 41834897

The Burden of Human Metapneumovirus (hMPV) Disease in Older and High-Risk Adults in Developed Countries: A Systematic Literature Review. PMID: 40742420

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Multiple Cerebral Hemorrhages and White Matter Lesions Developing after Severe hMPV Pneumonia in a Patient with Trisomy 13: A Case Report and Review of the Literature. PMID: 35793947

Molecular detection and genotyping of HMPV in patients with severe acute respiratory infection in India. PMID: 39221771

Safety and Immunogenicity of an mRNA-Based hMPV/PIV3 Combination Vaccine in Seropositive Children. PMID: 38738290

Substituted Carboxyamido-propanyl Compounds as Inhibitors of hRSV and hMPV to Treat Viral Respiratory Infections. PMID: 41257009

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