武汉艾必赛生物有限公司推荐Anti-HMPV N/Nucleoprotein Polyclonal Antibody,精品抗体

链接：https://www.abinscience.cn/product/34/12966.html

名称：Anti-HMPV N/Nucleoprotein Polyclonal Antibody

货号：VK571014

种属反应性：Human metapneumovirus (HMPV)

应用：ELISA, IHC, WB

宿主：Rabbit

克隆类型：Polyclonal

同种型：IgG

免疫原：E. coli - derived recombinant HMPV N/Nucleoprotein (Met1-Glu394).

靶标：Nucleoprotein, Protein N, Nucleocapsid protein, N

纯化方式：Purified by antigen affinity column.

Accession号：Q6WBA1

状态：Liquid

用途范围：仅用于科研

储存：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

 

产品介绍：Anti-HMPV N/Nucleoprotein Polyclonal Antibody (VK571014, RUO) 是艾必赛生物（abinScience）推出的兔源多克隆抗体（IgG），靶向人偏肺病毒（Human metapneumovirus, HMPV）的核衣壳蛋白 N，可作为 HMPV 感染检测、病毒复制机制研究及血清学/免疫组化 assay 的阳性参照与检测工具。该抗体以 E. coli 表达的重组 HMPV N 蛋白（Met1–Glu394） 为免疫原，经抗原亲和柱纯化，以液体形式保存在 0.01M PBS, pH 7.4（含 50% Glycerol, 0.05% Proclin 300） 中；频繁使用 2–8°C，长期建议 -20°C 至 -80°C（自收货日起 ≤12 个月）避反复冻融。推荐应用于 ELISA（1:5000–1:20000）、IHC（1:50–1:500）、WB（1:500–1:2000）。（RUU，仅限科研/非临床用途）

人偏肺病毒（HMPV） 属副黏病毒科肺病毒属，为有囊膜单股负链 RNA 病毒，是婴幼儿、老年人及免疫低下人群急性呼吸道感染的重要病原，临床可表现为咳嗽、发热、喘息，重症可进展为毛细支气管炎或肺炎。病毒基因组由 N、P、M、F、M2、SH、G、L 等基因依次排列，其中 N 蛋白（~43 kDa） 是最丰富的结构蛋白——它通过沿 RNA 链寡聚化形成左手螺旋核衣壳（nucleocapsid），将负链 RNA 基因组紧密包裹，既保护病毒核酸免受核酸酶降解，也作为核糖核蛋白复合物（RNP）模板供 P/L 聚合酶进行转录与复制，是病毒生命周期的核心骨架。

因此，N 蛋白不仅是 HMPV 病毒复制、包涵体形成与装配研究的关键靶标，也因其高丰度与高保守性，成为感染组织染色、抗原检测、快速诊断 ELISA 开发及疫苗免疫原性评价的理想参照分子。

 

 

 

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邮箱：info@abinscience.com

参考文献：

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Human Metapneumovirus and Respiratory Syncytial Virus in Children: A Comparative Analysis. PMID: 40763933

Profiling of hMPV F-specific antibodies isolated from human memory B cells. PMID: 35538099

The global burden of human metapneumovirus-associated acute respiratory infections in older adults: a systematic review and meta-analysis. PMID: 39954700

[Human metapneumovirus]. PMID: 17446666

Epidemiology of HMPV and Other Respiratory Viral Infections Among Outpatients, 2016-2022. PMID: 41834897

Antibody Epitopes of Pneumovirus Fusion Proteins. PMID: 31849961

Non-Coding RNAs and Their Role in Respiratory Syncytial Virus (RSV) and Human Metapneumovirus (hMPV) Infections. PMID: 32245206

Rational design of uncleaved prefusion-closed trimer vaccines for human respiratory syncytial virus and metapneumovirus. PMID: 39550381

Virus vaccines: proteins prefer prolines. PMID: 33705704

Neonatal Immune Responses to Respiratory Viruses. PMID: 35493465

Structures of the Mononegavirales Polymerases. PMID: 32847861

Safety and Immunogenicity of an mRNA-Based hMPV/PIV3 Combination Vaccine in Seropositive Children. PMID: 38738290

Human Metapneumovirus (hMPV) Infection and MPV467 Treatment in Immunocompromised Cotton Rats Sigmodon hispidus. PMID: 36851691

Early-life viral infection generates pathological tissue-resident memory cells that contribute to asthma-like disease. PMID: 41805545

Intranasal bovine/human parainfluenza virus 3 vaccine candidates expressing human metapneumovirus wild-type or pre-fusion F protein elicit protective immunity against human metapneumovirus in hamsters. PMID: 41288380

Severity of Respiratory Syncytial Virus and Other Respiratory Viruses Versus Seasonal Influenza Among Hospitalized Patients With Cancer. PMID: 41356264

Molecular detection and genotyping of HMPV in patients with severe acute respiratory infection in India. PMID: 39221771

Molecular Epidemiology of Human Metapneumovirus Infections in Children from San Luis Potosí-Mexico. PMID: 41157609

Recent vaccine development for human metapneumovirus. PMID: 25667325

IFITM3 Restricts Human Metapneumovirus Infection. PMID: 29917090

Detection of hMPV antigen by EIA in clinical specimens. PMID: 22184941

Differential Responses of Pediatric and Adult Primary Epithelial Cells to Human Metapneumovirus and Respiratory Syncytial Virus Infection. PMID: 40143308

Structure of the N-RNA/P interface indicates mode of L/P recruitment to the nucleocapsid of human metapneumovirus. PMID: 37993464

Characterization of the Interaction Domains between the Phosphoprotein and the Nucleoprotein of Human Metapneumovirus. PMID: 34730389

Development of a potent monoclonal antibody for treatment of human metapneumovirus infections. PMID: 41680141

Emergence and epidemiology of dominant variants of human metapneumovirus in the United States between 2016 and 2021. PMID: 41524405

Avian and human metapneumovirus. PMID: 17470912

N(6)-methyladenosine modification enables viral RNA to escape recognition by RNA sensor RIG-I. PMID: 32015498

Bronchiolitis Due to RSV and HMPV-Epidemiology, Clinical Course, and Prognosis: Experience of a Single Tertiary Center. PMID: 36744682

Cross-protective antibodies against common endemic respiratory viruses. PMID: 36781872

Human Metapneumovirus Phosphoprotein Independently Drives Phase Separation and Recruits Nucleoprotein to Liquid-Like Bodies. PMID: 35536005

Household transmission of human metapneumovirus and seasonal coronavirus. PMID: 38770587

Interactions between the Nucleoprotein and the Phosphoprotein of Pneumoviruses: Structural Insight for Rational Design of Antivirals. PMID: 34960719

Development of a rapid chromatographic immunoassay for detection of human metapneumovirus using monoclonal antibodies against nucleoprotein of hMPV. PMID: 17316081

Novel insights into the host cell glycan binding profile of human metapneumovirus. PMID: 38690874

[Epidemiology and clinical characteristics of human metapneumovirus]. PMID: 40684432

Bugs and asthma: a different disease? PMID: 19387028

 

 

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武汉艾必赛生物技术有限公司成立于 2023 年，是 abinScience 在亚洲地区设立的官方全资子公司，全面负责 abinScience 品牌在亚太市场的科研试剂推广、销售及技术支持工作。
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