链接：https://www.abinscience.cn/product/40/4316.html
名称：Anti-Human CD3 Antibody (SP34)
Accession号：P07766
货号：HY057507
种属反应性：Human
宿主：Mouse
形式：Liquid
纯度：>95% as determined by SDS-PAGE.
克隆性：Monoclonal
同种型：IgG2a, kappa
应用：FCM
靶点：T3E, T-cell surface antigen T3/Leu-4 epsilon chain, CD3e, CD3E, T-cell surface glycoprotein CD3 epsilon chain
用途范围：仅用于科研
储存：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
产品介绍：Anti-Human CD3 Antibody (SP34) (HY057507) 是武汉艾必赛生物技术有限公司 (abinScience) 推出的一款高特异性小鼠源单克隆抗体。该抗体靶向人T细胞表面抗原T3/Leu-4的ε链 (T3E/CD3e)，此靶点是T细胞受体 (TCR) 复合物的关键组分，在T细胞的抗原识别与活化信号转导中发挥核心作用。本品克隆号为SP34，同种型为IgG2a, kappa，通过Protein A/G方法纯化，纯度经SDS-PAGE检测高于95%。该抗体经严格验证适用于流式细胞术 (FCM)，可特异性检测人源样本中CD3ε蛋白的表达。其经典的单克隆抗体结构确保了高度的特异性和批次间的一致性，是进行T细胞免疫分型、免疫功能研究及相关疾病机制探索的可靠工具试剂。
产品购买联系方式：027-87433958/17302791434
邮箱：info@abinscience.com
参考文献：
Cholesterol inhibits TCR signaling by directly restricting TCR-CD3 core tunnel motility. PMID: 35271814
Structural basis of assembly of the human T cell receptor-CD3 complex. PMID: 31461748
CD3(+)CD20(+) T cells and their roles in human diseases. PMID: 30639700
CD3 delta immunodeficiency. PMID: 15640687
Optimizing efficacy and safety of T cell bispecific antibodies: the interdependence of CD3 and tumor antigen binder affinities in FOLR1 and CEACAM5 2 + 1 TCBs. PMID: 41196029
Current Knowledge about CD3(+)CD20(+) T Cells in Patients with Multiple Sclerosis. PMID: 39201672
Engineered CD3 antibodies for immunosuppression. PMID: 12930354
CD3-specific antibody-induced active tolerance: from bench to bedside. PMID: 12563296
Characterization of CD3+/CD20+ canine large-cell lymphoma. PMID: 37837199
Back on the scene: Advances and challenges in CD3-related drugs in tumor therapy. PMID: 35489674
Discordant CD3 expression in lymphomas when studied on frozen and paraffin sections. PMID: 7557948
Structure-based engineering of a novel CD3ε-targeting antibody for reduced polyreactivity. PMID: 36991534
Muromonab CD3: a reappraisal of its pharmacology and use as prophylaxis of solid organ transplant rejection. PMID: 8861551
CD3 zeta defects in systemic lupus erythematosus. PMID: 22460144
Combining CD3/GD2 bispecific T cell engager with human Vgamma9Vdelta2 T cells facilitates neuroblastoma cell targeting and killing in vitro. PMID: 40489497
Internalization and intracellular fate of TCR-CD3 complexes. PMID: 11100805
[CD3 subunit deficiencies]. PMID: 11212834
Key links in the physiological regulation of the immune system and disease induction: T cell receptor -CD3 complex. PMID: 39029632
Rigid crosslinking of the CD3 complex leads to superior T cell stimulation. PMID: 39281668
Atomic-resolution view of complete TCR-CD3 revealed. PMID: 31907795
CD3+ Tumor-Infiltrating Lymphocytes in Breast Carcinoma: Their Prognostic Role and Association With Clinical Parameters. PMID: 39791074
The TCR/CD3 complex: molecular interactions in a changing structure. PMID: 12371622
The novel CD16A/anti-CD3 bifunctional protein, eCD16A/anti-CD3-BFP, redirects T cell cytotoxicity toward antibody-bound target cells. PMID: 39763374
CD3(+)CD8(+)CD28(-) T Lymphocytes in Patients with Lupus Nephritis. PMID: 27446964
Changing roles of CD3 + CD8 low T cells in combating HIV-1 infection. PMID: 36580634
T-cell-receptor isoforms. PMID: 1428396
Expansion of mixed immune cells using CD3/CD161 co-stimulation for the treatment of cancer. PMID: 37100864
CD3+ T cell depletion paradoxically worsens intracerebral hemorrhage through blood-brain barrier disruption. PMID: 40985817
Can we define CD3(+)CD56(+) cells as NKT cells with impunity? PMID: 33662591
Composition of TCR-CD3 complex in human intestinal intraepithelial lymphocytes: lack of Fc epsilon RI gamma chain. PMID: 7495730
T cell inactivation and cytokine deviation promoted by anti-CD3 mAbs. PMID: 9368773
Moniezia benedeni drives CD3(+) T cells residence in the sheep intestinal mucosal effector sites. PMID: 38371601
Use of CD3 antibodies in transplantation and autoimmune diseases. PMID: 7998111
Proinflammatory CD20(+)CD3(+) T cells as a potential driver of macrophage reprogramming in rheumatoid arthritis. PMID: 41411762
The CD3 epsilon subunit of the TCR contains endocytosis signals. PMID: 10384095
Human CD3(+)CD56(+)NKT-like cells express a range of complement receptors and C3 activation has negative effects on these cell activity and effector function. PMID: 34134908
Implicit Flow Cytometric Diagnosis of Classic Hodgkin Lymphoma Using CD3(+)CD4(+)CD26(-) T-Cells. PMID: 39235202
CD3 zeta and eta chains are produced by alternative splicing from a common gene. PMID: 2150596
The phenotype of CD3-CD56(bright) and CD3-CD56(dim) natural killer cells in systemic lupus erythematosus patients and its relation to disease activity. PMID: 36186836
详情请咨询 abinScience 亚洲区官方子公司 —— 武汉艾必赛生物技术有限公司
武汉艾必赛生物技术有限公司成立于 2023 年，是 abinScience 在亚洲地区设立的官方全资子公司，全面负责 abinScience 品牌在亚太市场的科研试剂推广、销售及技术支持工作。
依托严格的产品研发体系和国际化的质量管理标准，武汉艾必赛与 AtaGenix、ProteoGenix 等知名品牌保持长期战略合作，现已构建起涵盖抗体、重组蛋白、工具酶、试剂盒、实验耗材在内的多品类供应体系，面向区域内科研机构、高校实验室与生物医药企业，提供稳定、高效、可信赖的产品与服务。
核心业务覆盖：
? 抗体产品（单抗、多抗、重组抗体等）
? 蛋白与多肽试剂（标签蛋白、功能蛋白等）
? 分子与细胞实验相关耗材
? 定制化研发服务（蛋白表达、抗体定制、亲和力成熟等）
? 科研供应链整合与项目配套支持
武汉艾必赛始终秉持“Empowering Bioscience Discovery”的理念，为亚太地区的生命科学研究持续注入高质量动能。
返回顶部
