链接：https://www.abinscience.cn/product/78/54997.html
名称：Recombinant FMDV (SAT-1) VP1 Protein, N-His
Accession号：A0A7L4XQ62
货号：VK500132
种属：Foot-and-mouth disease virus SAT 1
表达系统：E. coli
状态：Lyophilized
纯度：>90% as determined by SDS-PAGE.
蛋白长度：Thr725-Gln943
应用：ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
预测分子量 26.64 kDa
用途范围：仅用于科研
储存： Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
产品介绍：近期，我国首次发生输入性南非1型（SAT1）口蹄疫疫情，该血清型为非洲特有毒株，与我国长期流行的 O 型、A 型、亚洲 1 型等毒株在基因组、衣壳结构、抗原蛋白组成及表位构象上存在本质区别，不同血清型间无交叉免疫保护，现有常规疫苗无法提供有效保护。
Recombinant FMDV (SAT-1) VP1 Protein, N-His (VK500132)是武汉艾必赛生物科技有限公司（abinScience）推出的一款高纯度、高免疫原性的重组病毒蛋白。该产品为口蹄疫病毒（FMDV）南非1型（SAT-1）的衣壳蛋白VP1，携带N端组氨酸（His）标签，采用大肠杆菌系统表达并纯化。VP1蛋白是口蹄疫病毒的主要衣壳蛋白和关键抗原，负责病毒与宿主细胞受体的结合，并能诱导机体产生中和抗体，是研究病毒致病机制、开发诊断试剂及亚单位疫苗的核心原料。
产品购买联系方式：027-87433958/17302791434
邮箱：info@abinscience.com
参考文献：
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2. FMDV 3A Antagonizes the Effect of ANXA1 to Positively Modulate Viral Replication. PMID: 35604142
3. Cmss1 limits FMDV infection by enhancing antigen presentation and CD8(+) T cell responses. PMID: 41277842
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A review of foot-and-mouth disease virus (FMDV) testing in livestock
with an emphasis on the use of alternative diagnostic specimens. PMID:
30345947
5.
Foot-and-mouth disease virus (FMDV) negatively regulates ZFP36 protein
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6. FMDV Leader Protein Interacts with the NACHT and LRR Domains of NLRP3 to Promote IL-1beta Production. PMID: 35062226
7. MicroRNA-4331-5p promotes FMDV replication through inhibiting interferon pathways in PK-15 cells. PMID: 32574680
8. Multiple-Site SUMOylation of FMDV 3C Protease and Its Negative Role in Viral Replication. PMID: 36005757
9.
Ribosomal protein L35 negatively regulates FMDV replication by
recruiting AMFR to promote the ubiquitination and degradation of VP2.
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10.
3C(pro) of FMDV inhibits type II interferon-stimulated JAK-STAT
signaling pathway by blocking STAT1 nuclear translocation. PMID:
36921803
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12.
Small Molecules Targeting 3C Protease Inhibit FMDV Replication and
Exhibit Virucidal Effect in Cell-Based Assays. PMID: 37766293
13. Mutation of FMDV L(pro) H138 residue drives viral attenuation in cell culture and in vivo in swine. PMID: 36387381
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The Host Protein CAD Regulates the Replication of FMDV through the
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Enhanced antigen-specific CD8 T cells contribute to early protection
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16. DDX21, a Host Restriction Factor of FMDV IRES-Dependent Translation and Replication. PMID: 34578346
17. RNA-Seq analysis reveals the different mechanisms triggered by bovine and equine after infection with FMDV. PMID: 39287214
18.
Assessment on Different Vaccine Formulation Parameters in the
Protection against Heterologous Challenge with FMDV in Cattle. PMID:
36016403
19. Development of a competitive ELISA method based on VLPs detecting the antibodies of serotype A FMDV. PMID: 34915087
20. Phospholipase PLA2G16 Accelerates the Host Interferon Signaling Pathway Response to FMDV. PMID: 40733501
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23.
Development and Validation of Serotype-Specific Blocking ELISA for the
Detection of Anti-FMDV O/A/Asia1/SAT2 Antibodies. PMID: 39339914
24.
A genome-wide CRISPR screening uncovers that TOB1 acts as a key host
factor for FMDV infection via both IFN and EGFR mediated pathways. PMID:
38512977
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27.
Meta-analysis of genetic diversity of VP1 gene of foot and mouth
disease virus serotypes prevalent in Bangladesh from 2010 to 2024. PMID:
41043698
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29.
Differentiation of the seven serotypes of foot-and-mouth disease virus
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Characterization of foot-and-mouth disease viruses (FMDVs) from Ugandan
cattle outbreaks during 2012-2013: evidence for circulation of multiple
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31.
Characterisation of recent foot-and-mouth disease viruses from African
buffalo (Syncerus caffer) and cattle in Kenya is consistent with
independent virus populations. PMID: 25644407
32. Molecular Characterization of Foot-and-Mouth Disease Viruses Collected in Tanzania Between 1967 and 2009. PMID: 24460931
33.
Pervasive within-host recombination and epistasis as major determinants
of the molecular evolution of the foot-and-mouth disease virus capsid.
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Analysis of Recent Serotype O Foot-and-Mouth Disease Viruses from
Livestock in Kenya: Evidence of Four Independently Evolving Lineages.
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36. Genetic heterogeneity in the foot-and-mouth disease virus Leader and 3C proteinases. PMID: 12036580
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Demonstration of antigenic site 3 in foot-and-mouth disease virus
serotype A using neutralizing monoclonal antibody resistant mutants.
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Development and evaluation of tailored specific real-time RT-PCR assays
for detection of foot-and-mouth disease virus serotypes circulating in
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武汉艾必赛生物技术有限公司成立于 2023 年，是 abinScience 在亚洲地区设立的官方全资子公司，全面负责 abinScience 品牌在亚太市场的科研试剂推广、销售及技术支持工作。
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