武汉艾必赛生物有限公司推荐InVivoMAb Anti-SEBOV/ZEBOV GP/Envelope glycoprotein Antibody (Iv0198) ,精品抗体

链接：https://www.abinscience.cn/product/68/16504.html

名称：InVivoMAb Anti-SEBOV/ZEBOV GP/Envelope glycoprotein Antibody (Iv0198)

货号：VK623050

种属反应性：Ebola virus, Zaire ebolavirus, Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus), Sudan ebolavirus (strain Human/Uganda/Gulu/2000) (SEBOV) (Sudan Ebolavirus)

应用：ELISA, FCM, Neutralization

宿主：Human

同种型：IgG

克隆号：Iv0198

克隆类型：Monoclonal

靶标：Envelope glycoprotein, GP1, 2, GP, Shed GP, GP1, 2-delta, GP1, GP2, GP

内毒素水平：Please contact with the lab for this information.

纯度：>95% as determined by SDS-PAGE.

纯化方式：Protein A/G purified from cell culture supernatant.

Accession号：P87666, O11457, Q05320, Q9YMG2, P0C773, Q7T9D9

状态：Liquid

用途范围：仅用于科研

储存：Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

产品介绍：InVivoMAb Anti-SEBOV/ZEBOV GP/Envelope glycoprotein Antibody (Iv0198)｜VK623050 是艾必赛生物（abinScience）推出的人源单克隆抗体（人 IgG），靶向扎伊尔埃博拉病毒（ZEBOV, strain Mayinga-76）与苏丹埃博拉病毒（SEBOV, Gulu/2000）的包膜糖蛋白 GP，可同时交叉识别两种高危埃博亚型，适用于 ELISA、流式（FCM）及中和实验（Neutralization），也可作为体内（In Vivo）研究级抗体使用。该抗体经 Protein A/G 纯化，纯度 >95%（SDS-PAGE），以液体形式保存在 0.01M PBS, pH 7.4 中；短期 4°C（1–2 周），长期建议 -20°C（≤12 个月）/ -80°C 避反复冻融。（RUO，仅限科研/非临床用途）

埃博拉病毒归类于丝状病毒科，为单股负链 RNA 病毒，其中扎伊尔型（ZEBOV）致死率最高（可 >50%），苏丹型（SEBOV）亦具高致病性。人际传播以接触患者/死者血液、体液及污染物为主，早期表现为高热、肌痛、胃肠症状，重症进展为血管内皮损伤、凝血障碍、多器官衰竭及出血。病毒表面 GP（GP1,2）三聚体刺突通过 GP1 结合宿主受体（如 NPC1 通路）、GP2 介导膜融合完成入侵，同时 GP 还可下调整合素表达、扰乱免疫监视，是中和抗体、抗病毒药物及疫苗的核心靶点。Iv0198 能同时覆盖 ZEBOV 与 SEBOV 两种 GP，适合用于跨毒株血清学检测、流式分型、中和效价评估及体内保护实验的方法搭建与对照设置。

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邮箱：info@abinscience.com

参考文献：

Structures and Functions of the Envelope Glycoprotein in Flavivirus Infections. PMID: 29137162
Maturation of HIV envelope glycoprotein precursors by cellular endoproteases. PMID: 11063880
Single-molecule localisation microscopy approaches reveal envelope glycoprotein clusters in single-enveloped viruses: a potential functional role? PMID: 40495469
Viral envelope glycoprotein processing by proprotein convertases. PMID: 23611717
Postfusion structure of human-infecting Bourbon virus envelope glycoprotein. PMID: 31419524
Mapping glycoprotein structure reveals Flaviviridae evolutionary history. PMID: 39232167
Characterization of the dengue virus envelope glycoprotein expressed in Pichia pastoris. PMID: 17502678
Alpharetrovirus envelope-receptor interactions. PMID: 12932076
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Envelope proteins as antiviral drug target. PMID: 32643453
Human cytomegalovirus glycoproteins. PMID: 9130049
IFITM1 and IFITM3 Proteins Inhibit the Infectivity of Progeny HIV-1 without Disrupting Envelope Glycoprotein Clusters. PMID: 38140631
Human immunodeficiency virus type 1 envelope glycoprotein is modified by O-linked oligosaccharides. PMID: 8254757
Functional regions of the envelope glycoprotein of human immunodeficiency virus type 1. PMID: 3629244
Virus glycoprotein nanodisc platform for vaccine analytics. PMID: 41667448
Budding of alphaviruses. PMID: 15567491
The SARS-CoV S glycoprotein. PMID: 15526150
Extracellular vaccinia virus envelope glycoprotein encoded by the A33R gene. PMID: 8648710
Human MARCH1, 2, and 8 block Ebola virus envelope glycoprotein cleavage via targeting furin P domain. PMID: 38299743
MARCH8 Inhibits Ebola Virus Glycoprotein, Human Immunodeficiency Virus Type 1 Envelope Glycoprotein, and Avian Influenza Virus H5N1 Hemagglutinin Maturation. PMID: 32934085
Rat and human cytomegalovirus ORF116 encodes a virion envelope glycoprotein required for infectivity. PMID: 33601113
Guanylate-binding protein 5 antagonizes viral glycoproteins independently of furin processing. PMID: 39212413
Assembly of a functional HCV glycoprotein heterodimer. PMID: 17489436
Averaging of viral envelope glycoprotein spikes from electron cryotomography reconstructions using Jsubtomo. PMID: 25350719
MARCH8 Targets Cytoplasmic Lysine Residues of Various Viral Envelope Glycoproteins. PMID: 35019698
Research Note: Duck plague virus glycoprotein I influences cell-cell spread and final envelope acquisition. PMID: 33248580
Assays to Assess Arenaviral Glycoprotein Function. PMID: 28986832
Biochemical reconstitution of hemorrhagic-fever arenavirus envelope glycoprotein-mediated membrane fusion. PMID: 23226473
Functional Relevance of the N-Terminal Domain of Pseudorabies Virus Envelope Glycoprotein H and Its Interaction with Glycoprotein L. PMID: 28228592
Assembly of arenavirus envelope glycoprotein GPC in detergent-soluble membrane microdomains. PMID: 19625404
Structure of a flavivirus envelope glycoprotein in its low-pH-induced membrane fusion conformation. PMID: 14963486
Analysis of the humoral immune response against the envelope glycoprotein Gc of Schmallenberg virus reveals a domain located at the amino terminus targeted by mAbs with neutralizing activity. PMID: 26684324
Characterization of human immunodeficiency virus type 2 envelope glycoproteins: dimerization of the glycoprotein precursor during processing. PMID: 2911118
Targeting retroviral and lentiviral vectors. PMID: 12932077

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