链接：https://www.abinscience.cn/product/40/306.html
名称：Anti-Human TSHR/LGR3 Antibody (M22)
别名：促甲状腺素受体TSHR/LGR3 Anti (M22)
货号：HB852107
适用物种：Human
寄主物种：Human
形式：Liquid
纯度：>95% as determined by SDS-PAGE.
克隆性：Monoclonal
同种型：IgG1
应用：FCM, SPR, IHC
UniProt：P16473
靶点：Thyroid-stimulating hormone receptor, TSH-R, TSHR, Thyrotropin receptor, LGR3
用途范围：仅用于科研
储存：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
产品介绍：Anti-Human TSHR/LGR3 Antibody (M22) 是人源单克隆抗体，靶向促甲状腺激素受体（TSHR，又称 LGR3）。TSHR 为 GPCR 家族成员，主要表达于甲状腺滤泡细胞，介导 TSH 信号调控甲状腺激素合成与分泌；其异常激活与格雷夫斯病等自身免疫甲状腺疾病密切相关。M22 可高亲和力结合 TSHR 并模拟 TSH 刺激效应，适用于 ELISA、流式、免疫组化及功能激活实验，广泛用于甲状腺自身抗体检测、受体信号机制研究及靶向药物开发。abinScience产品具有亲和力高，灵敏度高，特异性好，稳定性强等优势。
产品购买联系方式：027-87433958/17302791434
参考文献：
A review of TSHR- and IGF-1R-related pathogenesis and treatment of Graves' orbitopathy. PMID: 36742308
Local TSH/TSHR signaling promotes CD8(+) T cell exhaustion and immune evasion in colorectal carcinoma. PMID: 39285586
TSHR Gene (rs179247) Polymorphism and Susceptibility to Autoimmune Thyroid Disease: A Systematic Review and Meta-Analysis. PMID: 39086275
TSHR in thyroid cancer: bridging biological insights to targeted strategies. PMID: 40532044
Controversial constitutive TSHR activity: patients, physiology, and in vitro characterization. PMID: 24845969
Mechanisms of Action of TSHR Autoantibodies. PMID: 26361260
Modulation of TSHR signaling by posttranslational modifications. PMID: 17524661
Central Tolerance Mechanisms to TSHR in Graves' Disease: Contributions to Understand the Genetic Association. PMID: 30396220
TSHR Variant Screening and Phenotype Analysis in 367 Chinese Patients With Congenital Hypothyroidism. PMID: 38433572
Genetics of Graves' Disease: Special Focus on the Role of TSHR Gene. PMID: 26361261
A TSHR-Targeting Aptamer in Monocytes Correlating with Clinical Activity in TAO. PMID: 38650837
Signaling Dynamics of TSHR-Specific CAR-T Cells Revealed by FRET-Based Biosensors. PMID: 35252208
Presence of TSHR in NK Cells and Action of TSH on NK Cells. PMID: 34392245
TSHR-based chimeric antigen receptor T cell specifically deplete auto-reactive B lymphocytes for treatment of autoimmune thyroid disease. PMID: 37690235
Central dogma in thyroid dysfunction: a review on structure modification of TSHR as a cornerstone for thyroid abnormalities. PMID: 21870640
Association between TSHR gene methylation and papillary thyroid cancer: a meta-analysis. PMID: 32279226
Genetic defects, thyroid growth and malfunctions of the TSHR in pediatric patients. PMID: 20515734
Thyroid-stimulating hormone receptor (TSHR) fusion proteins in Graves' disease. PMID: 32573180
TSHR Signaling Stimulates Proliferation Through PI3K/Akt and Induction of miR-146a and miR-155 in Thyroid Eye Disease Orbital Fibroblasts. PMID: 31622470
PET Imaging of Differentiated Thyroid Cancer with TSHR-Targeted [(89)Zr]Zr-TR1402. PMID: 38976794
Variant of TSHR is Not a Frequent Cause of Congenital Hypothyroidism in Chinese Han Patients. PMID: 34377013
The Role of TSHR, PTEN and RASSF1A Promoters' Methylation Status for Non-Invasive Detection of Papillary Thyroid Carcinoma. PMID: 36013156
EFFECT OF THE C-TERMINUS OF TSHR ON T4 AND TRAB EXPRESSION IN BALB/C MICE. PMID: 37908889
Liver-specific deletion of TSHR inhibits hepatic lipid accumulation in mice. PMID: 29421660
Mutation screening of the TSHR gene in 220 Chinese patients with congenital hypothyroidism. PMID: 31356790
Polymorphisms in TSHR gene and the risk and prognosis of autoimmune thyroid disease in Tunisian population. PMID: 32685031
TSHR Gene Polymorphisms in the Enhancer Regions Are Most Strongly Associated with the Development of Graves' Disease, Especially Intractable Disease, and of Hashimoto's Disease. PMID: 27762730
Crosstalk Between Abnormal TSHR Signaling Activation and PTEN/PI3K in the Dedifferentiation of Thyroid Cancer Cells. PMID: 34650915
Downregulated expression of TSHR is associated with distant metastasis in thyroid cancer. PMID: 29344196
Thyrotropin Receptor Blocking Antibodies. PMID: 30286485
A Novel TSHR Gene Mutation in a Family with Non-autoimmune Hyperthyroidism. PMID: 38566871
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