武汉艾必赛生物有限公司推荐Anti-Human FOLR1 Reference Antibody (Sofetabart, RUO) ,精品抗体

链接：https://www.abinscience.cn/product/34/56319.html

名称：Anti-Human FOLR1 Reference Antibody (Sofetabart, RUO)

货号：HB825106

种属反应性：Human

应用：ELISA, FACS, Functional assay

宿主：Human

同种型：IgG1, kappa

克隆类型：Monoclonal

靶标：Adult folate-binding protein, FBP, FOLR, FOLR1, FR-alpha, Folate receptor 1, Folate receptor alpha, Folate receptor, adult, KB cells FBP, Ovarian tumor-associated antigen MOv18

内毒素水平：< 10 EU/mg

纯度：>95% as determined by SDS-PAGE.

纯化方式：Protein A/G purified from cell culture supernatant.

Accession号：P15328

状态：Liquid

用途范围：仅用于科研

储存：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

产品介绍：Anti-Human FOLR1 Reference Antibody (Sofetabart, RUO)｜HB825106 是艾必赛生物（abinScience）推出的人源化单克隆参照抗体（人 IgG1-kappa），靶向人叶酸受体 α（FOLR1/FRα），可作为 FRα 阳性肿瘤药物（如 Sofetabart mipitecan 等 FRα-ADC）PK/PD 研究、ELISA/FACS/功能性 assay 以及 ADA 方法开发的阳性/药物参照质控工具。该抗体在哺乳动物细胞中表达，糖基化更接近天然构象，经 Protein A/G 纯化，纯度 >95%（SDS-PAGE），以液体形式保存在 0.01M PBS, pH 7.4 中；频繁使用 2–8°C，长期建议 -20°C 至 -80°C（自收货日起 ≤12 个月）避反复冻融。（RUO，仅限科研/非临床用途）

FOLR1（FRα） 是由 FOLR1 基因编码的约 29 kDa 细胞表面糖蛋白，以高亲和力结合叶酸及还原型叶酸衍生物，通过 potocytosis 介导叶酸内吞，为快速增殖细胞提供一碳代谢与 DNA 合成所需底物。FRα 在正常组织中表达受限，却在卵巢癌、子宫内膜癌、非小细胞肺癌、结直肠癌等多种实体瘤中显著上调，因此成为抗体偶联药物（ADC）、单抗、双抗及 CAR-T 等肿瘤药物研发的热门靶点。其中礼来开发的 Sofetabart mipitecan（LY4170156） 由 Fc 沉默的人源化 IgG1 抗体 Sofetabart 通过可裂解聚肌氨酸（PSARlink?）连接子偶联拓扑异构酶 I 抑制剂 exatecan 构成，DAR 达 8:1，已在铂耐药卵巢癌等领域推进至 III 期临床，并于 2026 年 1 月获 FDA 突破性疗法认定。HB825106 作为 Sofetabart 的科研级参照抗体，可为 FRα 靶向药物的亲和力评估、流式细胞术结合实验、ADCC/CDC 功能性 bioassay 以及 PK/ADA ELISA 平台搭建提供可靠的阳性对照与校准基准，是 FRα 管线生物类似药开发与表征工作流中的配套试剂。

产品购买联系方式：027-87433958/17302791434

邮箱：info@abinscience.com

参考文献：

Cerebral Folate Deficiency Syndrome: Early Diagnosis, Intervention and Treatment Strategies. PMID: 35956272

Analysis of real world FRα testing in ovarian, fallopian tube, and primary peritoneal cancers. PMID: 39631181

Heterogeneity and Scoring Reproducibility of Folate Receptor 1 Immunohistochemistry in High-grade Serous Carcinoma. PMID: 41217393

Folate receptors and neural tube closure. PMID: 28244241

Interobserver Agreement in Immunohistochemical Evaluation of Folate Receptor Alpha (FRα) in Ovarian Cancer: A Multicentre Study. PMID: 40869006

Reduced folate receptor alpha (FOLR1) protein expression in fallopian tubes from premenopausal women: implications for the FOLR1 CDx assay for mirvetuximab-soravtansine therapy. PMID: 42023640

Conditions associated with circulating tumor-associated folate receptor 1 protein in healthy men and women. PMID: 24810481

Cardiovascular abnormalities in Folr1 knockout mice and folate rescue. PMID: 17286298

Expression of genes FOLR1, BAG1 and LAPTM4B in functioning and non-functioning pituitary adenomas. PMID: 23023342

[Environment and genetics in the etiology of cleft lip and cleft palate with reference to the role of folic acid]. PMID: 10748547

Clinicopathological and immunohistochemical characteristics of breast cancer patients from Northeast India with special reference to triple negative breast cancer: A prospective study. PMID: 32044043

Identification of key genes and immune cell infiltration in recurrent implantation failure: A study based on integrated analysis of multiple microarray studies. PMID: 35929523

The dynamic dysregulated network identifies stage-specific markers during lung adenocarcinoma malignant progression and metastasis. PMID: 36514354

Mutations in folate transporter genes and risk for human myelomeningocele. PMID: 28948692

Determination of CSF 5-methyltetrahydrofolate in children and its application for defects of folate transport and metabolism. PMID: 27363740

Results of the First Folate Receptor Alpha Testing Trial by the German Quality Assurance Initiative in Pathology (QuIP®). PMID: 41301065

Evaluation of thymidine kinase 1 and folate receptor alpha as potential biomarkers in prostate cancer. PMID: 40830177

Mutations in exons 2 and 3 of the FOLR1 gene in demented and non-demented elderly subjects. PMID: 17912458

Diagnostic approach to neurotransmitter monoamine disorders: experience from clinical, biochemical, and genetic profiles. PMID: 28924877

Cerebral folate transporter deficiency syndrome in three siblings: Why genetic testing for developmental and epileptic encephalopathies should be performed early and include the FOLR1 gene. PMID: 34008900

Heterogeneous graph neural networks reveal molecular mechanisms of folate deficiency in placental insufficiency through multiomics integration. PMID: 41673068

Simultaneous measurement of monoamine metabolites and 5-methyltetrahydrofolate in the cerebrospinal fluid of children. PMID: 27940130

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