链接：https://www.abinscience.cn/product/34/15867.html
名称：Anti-Human CD212/IL12RB1 Nanobody (SAA1300)
Accession号：P42701
货号：HW512013
种属反应性：Human
宿主：Alpaca
形式：Liquid
纯度：>95% as determined by SDS-PAGE.
克隆性：Monoclonal
同种型：VHH-8His-Cys-tag
应用：ELISA, FCM, SPR
靶点：IL-12 receptor beta component, CD212, IL-12R-beta-1, IL-12RB1, IL12RB1, Interleukin-12 receptor subunit beta-1, IL-12 receptor subunit beta-1, IL12R, IL-12R subunit beta-1, IL12RB
用途范围：仅用于科研
储存：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
产品介绍：Anti-Human CD212/IL12RB1 Nanobody (SAA1300) 是武汉艾必赛生物技术有限公司推出的一款高特异性、高亲和力的羊驼源单克隆纳米抗体。该抗体靶向人白细胞介素-12受体β1亚基 (IL-12RB1/CD212)，该靶点是IL-12信号通路中的关键组分，在调节T细胞和NK细胞的免疫应答中发挥核心作用。本品克隆号为SAA1300，通过镍柱纯化，纯度超过95%，经严格验证适用于酶联免疫吸附试验 (ELISA)、流式细胞术 (FCM) 及表面等离子共振 (SPR) 等多种前沿实验技术。其VHH单域抗体结构赋予其分子量小、稳定性高、易于工程化改造等独特优势，是研究Th1细胞分化、自身免疫性疾病、肿瘤免疫及开发相关靶向疗法的理想工具试剂。
产品购买联系方式：027-87433958/17302791434
邮箱：info@abinscience.com
1、[Analysis of IFN-gammaR1 (CD119) and IL-12Rbeta1 (CD212) Deficiency by Flow Cytometry]. PMID: 36636848
2、Preventing Surgery-Induced NK Cell Dysfunction Using Anti-TGF-β Immunotherapeutics. PMID: 36498937
3、The Virulence of Different Vaccinia Virus Strains Is Directly Proportional to Their Ability To Downmodulate Specific Cell-Mediated Immune Compartments In Vivo. PMID: 30567985
4、A Method of Assessment of Human Natural Killer Cell Phenotype and Function in Whole Blood. PMID: 32508837
5、Levocetirizine modulates lymphocyte activation in patients with allergic rhinitis. PMID: 18946193
6、CD34 defines an osteoprogenitor cell population in mouse bone marrow stromal cells. PMID: 26413784
7、Evidence for increased expression of regulatory cytokine receptors interleukin-12R and interleukin-18R in common variable immunodeficiency. PMID: 14616794
8、Potentiation of natural killer (NK) cell activity by methanol extract of cultured cambial meristematic cells of wild ginseng and its mechanism. PMID: 26141997
9、Discovering the link between IL12RB1 gene polymorphisms and tuberculosis susceptibility: a comprehensive meta-analysis. PMID: 38317798
10、Human IL12RB1 expression is allele-biased and produces a novel IL12 response regulator. PMID: 29599514
11、IL12RB1 allele bias in human T(H) cells is regulated by functional SNPs in its 3'UTR. PMID: 36007427
12、IL-12Rbeta1 deficiency: mutation update and description of the IL12RB1 variation database. PMID: 23864330
13、IL12RB1 Deficiency Appearing in North America: Expanding the Clinical Phenotypes. PMID: 41248676
14、Immune Correlates of Disseminated BCG Infection in IL12RB1-Deficient Mice. PMID: 35891311
15、Synergistic role of gut-microbial L-ornithine in enhancing ustekinumab efficacy for Crohn's disease. PMID: 39978335
16、An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs. PMID: 34033851
18、Primary Immune Regulatory Disorders With an Autoimmune Lymphoproliferative Syndrome-Like Phenotype: Immunologic Evaluation, Early Diagnosis and Management. PMID: 34447369
19、Leukocytoclastic vasculitis in patients with IL12B or IL12RB1 deficiency: case report and review of the literature. PMID: 34389021
20、Genetic, immunologic, and clinical features of 830 patients with Mendelian susceptibility to mycobacterial diseases (MSMD): A systematic review. PMID: 38341181
21、Three novel compound heterozygous IL12RB1 mutations in Chinese patients with Mendelian susceptibility to mycobacterial disease. PMID: 30998751
22、Autosomal recessive IL12RB1 mutation: A case report of a Sudanese child and his father. PMID: 37063912
23、KLRB1 and IL12RB1 are pretherapeutic predictors of time to relapse in patients with psoriasis treated with IL-17 blockade. PMID: 41319713
24、Early control of Mycobacterium tuberculosis infection requires il12rb1 expression by rag1-dependent lineages. PMID: 22907814
25、IL12Rbeta1deltaTM is a secreted product of il12rb1 that promotes control of extrapulmonary tuberculosis. PMID: 25404030
26、A Novel Compound Heterozygous Mutation in the IL12RB1 Gene Causes Susceptibility To Mycobacterium Tilburgii Infection. PMID: 41026231
27、IL-12 drives the differentiation of human T follicular regulatory cells. PMID: 38968337
28、Association of IL12RB1 polymorphisms with pulmonary tuberculosis in adults in Morocco. PMID: 15243935
29、Compound Heterozygous Mutations of IL12RB1 in a Patient with Selective Defects in Th17 Differentiation. PMID: 32221732
30、Inflammatory signals direct expression of human IL12RB1 into multiple distinct isoforms. PMID: 23024274
31、Identification of IL12RB1 as a novel systemic sclerosis susceptibility locus. PMID: 25199642
32、Overcoming lung cancer immunotherapy resistance by combining nontoxic variants of IL-12 and IL-2. PMID: 37669107
33、Gastric cancer in three relatives of a patient with a biallelic IL12RB1 mutation. PMID: 25467645
34、IL12Rβ1: the cytokine receptor that we used to know. PMID: 25516297
35、A Syrian Refugee in Iraq Diagnosed as a Case of IL12RB1 Deficiency in Japan Using Dried Blood Spots. PMID: 30740107
36、Polymorphisms on IFNG, IL12B and IL12RB1 genes and paracoccidioidomycosis in the Brazilian population. PMID: 27223631
37、IL1B, IL4R, IL12RB1 and TNF gene polymorphisms are associated with Plasmodium vivax malaria in Brazil. PMID: 23217179
38、Mycobacterium tuberculosis infection induces il12rb1 splicing to generate a novel IL-12Rbeta1 isoform that enhances DC migration. PMID: 20212068
39、Association of the IL12RB1 promoter polymorphisms with increased risk of atopic dermatitis and other allergic phenotypes. PMID: 16159888
40、Interleukin 12 (IL12B), interleukin 12 receptor (IL12RB1) and interleukin 23 (IL23A) gene polymorphism in systemic lupus erythematosus. PMID: 15941730
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武汉艾必赛生物技术有限公司成立于 2023 年，是 abinScience 在亚洲地区设立的官方全资子公司，全面负责 abinScience 品牌在亚太市场的科研试剂推广、销售及技术支持工作。
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